Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury

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dc.contributor.authorDetsika, Maria G.en
dc.contributor.authorLianos, Elias A.en
dc.contributor.departmentVirginia Tech Carilion School of Medicineen
dc.date.accessioned2021-06-11T15:14:53Zen
dc.date.available2021-06-11T15:14:53Zen
dc.date.issued2021-01en
dc.description.abstractHeme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of carbon monoxide (CO). Recent studies uncovered a new cytoprotective role for heme oxygenase-1 (HO-1) by identifying a regulatory role on the complement control protein decay-accelerating factor. This is a key complement regulatory protein preventing dysregulation or overactivation of complement cascades that can cause kidney injury. Cell-specific targeting of HO-1 induction may, therefore, be a novel approach to attenuate complement-dependent forms of kidney disease.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3390/antiox10010060en
dc.identifier.eissn2076-3921en
dc.identifier.issue1en
dc.identifier.other60en
dc.identifier.pmid33418934en
dc.identifier.urihttp://hdl.handle.net/10919/103787en
dc.identifier.volume10en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjecthemeen
dc.subjectheme oxygenase-1 (HO-1)en
dc.subjectcomplementen
dc.subjectkidney injuryen
dc.titleRegulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injuryen
dc.title.serialAntioxidantsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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