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Opinion: Mathematical models: A key tool for outbreak response

dc.contributorVirginia Techen
dc.contributor.authorLofgren, Eric T.en
dc.contributor.authorHalloran, M. Elizabethen
dc.contributor.authorRivers, Caitlinen
dc.contributor.authorDrake, John M.en
dc.contributor.authorPorco, Travis C.en
dc.contributor.authorLewis, Bryan L.en
dc.contributor.authorYang, Wanen
dc.contributor.authorVespignani, Alessandroen
dc.contributor.authorShaman, Jeffreyen
dc.contributor.authorEisenberg, Joseph N.S.en
dc.contributor.authorEisenberg, Marisa C.en
dc.contributor.authorMarathe, Madhav V.en
dc.contributor.authorScarpino, Samuel V.en
dc.contributor.authorAlexander, Kathleen A.en
dc.contributor.authorMeza, Rafaelen
dc.contributor.authorFerrari, Matthew J.en
dc.contributor.authorHyman, James M.en
dc.contributor.authorMeyers, Lauren Ancelen
dc.contributor.authorEubank, Stephenen
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2017-10-27T17:45:21Zen
dc.date.available2017-10-27T17:45:21Zen
dc.date.issued2015-01-13en
dc.description.abstractThe 2014 outbreak of Ebola in West Africa is unprecedented in its size and geographic range, and demands swift, effective action from the international community. Understanding the dynamics and spread of Ebola is critical for directing interventions and extinguishing the epidemic; however, observational studies of local conditions have been incomplete and limited by the urgent need to direct resources to patient care. Mathematical and computational models can help address this deficiency through work with sparse observations, inference on missing data, and incorporation of the latest information. These models can clarify how the disease is spreading and provide timely guidance to policymakers. However, the use of models in public health often meets resistance (1), from doubts in peer review about the utility of such analyses to public skepticism that models can contribute when the means to control an epidemic are already known (2). Even when they are discussed in a positive light, models are often portrayed as arcane and largely inaccessible thought experiments (3). However, the role of models is crucial: they can be used to quantify the effect of mitigation efforts, provide guidance on the scale of interventions required to achieve containment, and identify factors that fundamentally influence the course of an outbreak.en
dc.identifier.doihttps://doi.org/10.1073/pnas.1423846112en
dc.identifier.issue2en
dc.identifier.urihttp://hdl.handle.net/10919/79825en
dc.identifier.volume112en
dc.language.isoen_USen
dc.publisherNASen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleOpinion: Mathematical models: A key tool for outbreak responseen
dc.title.serialPNASen
dc.typeEditorial materialen

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