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Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds

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dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.contributor.inventorDavalos, Rafael V.en
dc.contributor.inventorSano, Michael B.en
dc.contributor.inventorGarcia, Paulo A.en
dc.contributor.inventorRobertson, John L.en
dc.contributor.inventorNeal, II, Robert E.en
dc.date.accessed2019-02-15en
dc.date.accessioned2019-02-26T22:23:59Zen
dc.date.available2019-02-26T22:23:59Zen
dc.date.filed2011-11-23en
dc.date.issued2018-01-16en
dc.description.abstractThe present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber13989175en
dc.identifier.patentnumber9867652en
dc.identifier.urihttp://hdl.handle.net/10919/87829en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/52/676/098/0.pdfen
dc.language.isoenen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA61B18/14en
dc.subject.cpcA61K48/0075en
dc.subject.cpcA61M5/00en
dc.subject.cpcA61B18/1492en
dc.subject.cpcA61B2018/00613en
dc.subject.cpcA61B2018/1472en
dc.subject.cpcA61B2218/002en
dc.subject.cpcA61N1/327en
dc.titleIrreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffoldsen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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