Deactivation of Ascaris suum eggs using electroporation and sequential inactivation with chemical disinfection

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dc.contributor.authorNiven, C.en
dc.contributor.authorParker, C. B.en
dc.contributor.authorWolter, S. D.en
dc.contributor.authorDryzer, M. H.en
dc.contributor.authorArena, Christopher B.en
dc.contributor.authorStoner, B. R.en
dc.contributor.authorNgaboyamahina, E.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2020-12-11T13:21:27Zen
dc.date.available2020-12-11T13:21:27Zen
dc.date.issued2020-09en
dc.description.abstractElectroporation has been evaluated as a potential backend wastewater treatment for deactivation ofAscaris suumeggs in buffer solution. Initial results indicate that eggshell permeability is affected by the pulse train electric field strength and duration. Coupling electroporation with chemical exposure, using low concentrations of commercially available disinfectants, allows oxidizing agents to pass through the complex strata of theA. suumeggshell, specifically reaching the innermost embryonic environment, which leads to successful deactivation compared to either method used separately. The aim of this work is to identify and develop an alternative technique that efficiently inactivates helminth eggs present in wastewater.en
dc.description.notesThe authors acknowledge the funding for this work provided by grants, OPP1148486 and OPP1173370, from the Bill and Melinda Gates Foundation through Duke University's Center for WaSH-AID, and Dr Katelyn Sellgren, from Duke University's Center for WaSH-AID, for her invaluable help with microscopic observation of A. suum. The authors also acknowledge Roberta Parrott and the Marcus Center for Cellular Cures for their kindness and generosity in our use of their fluorescent microscope. All opinions, findings, and conclusions or recommendations expressed in this work are those of the authors and do not necessarily reflect the views of the Foundation, Duke, or the Center.en
dc.description.sponsorshipBill and Melinda Gates Foundation through Duke University's Center for WaSH-AID [OPP1148486, OPP1173370]; Duke University's Center for WaSH-AIDen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.2166/washdev.2020.192en
dc.identifier.issn2043-9083en
dc.identifier.issue3en
dc.identifier.urihttp://hdl.handle.net/10919/101085en
dc.identifier.volume10en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAscaris suumen
dc.subjectchemical disinfectionen
dc.subjecteggshell permeabilityen
dc.subjectelectroporationen
dc.subjecthelminth deactivationen
dc.subjectwastewater sanitationen
dc.titleDeactivation of Ascaris suum eggs using electroporation and sequential inactivation with chemical disinfectionen
dc.title.serialJournal of Water Sanitation and Hygiene for Developmenten
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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