Human substantia nigra and ventral tegmental area involvement in computing social error signals during the ultimatum game

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dc.contributor.authorHétu, Sébastienen
dc.contributor.authorLuo, Yien
dc.contributor.authorD’Ardenne, Kimberleeen
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorMontague, P. Readen
dc.date.accessioned2019-06-03T21:03:08Zen
dc.date.available2019-06-03T21:03:08Zen
dc.date.issued2017-08-17en
dc.description.abstractAs models of shared expectations, social norms play an essential role in our societies. Since our social environment is changing constantly, our internal models of it also need to change. In humans, there is mounting evidence that neural structures such as the insula and the ventral striatum are involved in detecting norm violation and updating internal models. However, because of methodological challenges, little is known about the possible involvement of midbrain structures in detecting norm violation and updating internal models of our norms. Here, we used high-resolution cardiacgated functional magnetic resonance imaging and a norm adaptation paradigm in healthy adults to investigate the role of the substantia nigra/ventral tegmental area (SN/VTA) complex in tracking signals related to norm violation that can be used to update internal norms. We show that the SN/VTA codes for the norm’s variance prediction error (PE) and norm PE with spatially distinct regions coding for negative and positive norm PE. These results point to a common role played by the SN/ VTA complex in supporting both simple reward-based and social decision making.en
dc.description.sponsorshipThis study was supported by a National Institute on Drug Abuse (NIDA) grant R01 DA11723, a National Institute of Mental Health (NIMH) grant 5R01MH085496-09. P.R.M. is supported by a Principal Research Fellowship from The Wellcome Trust. S.H. is supported by Fellowships from the Fonds de Recherche Sante´ (FRQS) and Canadian Institute of Health Research (CIHR).en
dc.format.extent11 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/scan/nsx097en
dc.identifier.issue12en
dc.identifier.urihttp://hdl.handle.net/10919/89724en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectdecision makingen
dc.subjectfMRIen
dc.subjectprediction erroren
dc.subjectsocial neuroscienceen
dc.subjectultimatum gameen
dc.titleHuman substantia nigra and ventral tegmental area involvement in computing social error signals during the ultimatum gameen
dc.title.serialSocial Cognitive and Affective Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Destination Area: Adaptive Brain and Behavior (ABB)