Perineuronal Net Dynamics in the Pathophysiology of Epilepsy

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dc.contributor.authorChaunsali, Lataen
dc.contributor.authorTewari, Bhanu P.en
dc.contributor.authorSontheimer, Haralden
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.date.accessioned2021-07-27T19:10:50Zen
dc.date.available2021-07-27T19:10:50Zen
dc.date.issued2021-05-27en
dc.description.abstractPerineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental disruption of PNNs. Perineuronal nets also regulate the intrinsic properties of the enclosed PV neurons thereby maintaining their inhibitory activity. Recent studies have implicated PNNs in central nervous system diseases as well as PV neuron dysfunction; consequently, they have further been associated with altered inhibition, particularly in the genesis of epilepsy. A wide range of seizure presentations in human and rodent models exhibit ECM remodeling with PNN disruption due to elevated protease activity. Inhibition of PNN proteolysis reduces seizure activity suggesting that PNN degrading enzymes may be potential novel therapeutic targets.en
dc.description.notesThe author(s) received no financial support for the research, authorship, and/or publication of this article: This work was supported by NIH Grants 1R01NS036692-01A1 and 1R01CA227149-01A1.en
dc.description.sponsorshipNIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [1R01NS036692-01A1, 1R01CA227149-01A1]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1177/15357597211018688en
dc.identifier.eissn1535-7511en
dc.identifier.issn1535-7597en
dc.identifier.other1.53575972110187E+016en
dc.identifier.urihttp://hdl.handle.net/10919/104413en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectperineuronal neten
dc.subjectextracellular matrixen
dc.subjectepilepsyen
dc.subjectseizureen
dc.subjectmatrix metalloproteinaseen
dc.subjectPV interneuronsen
dc.titlePerineuronal Net Dynamics in the Pathophysiology of Epilepsyen
dc.title.serialEpilepsy Currentsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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