Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus

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dc.contributor.authorSingh, Rishabhen
dc.contributor.authorSu, Jianminen
dc.contributor.authorBrooks, Justin M.en
dc.contributor.authorTerauchi, Akikoen
dc.contributor.authorUmemori, Hisashien
dc.contributor.authorFox, Michael A.en
dc.date.accessioned2018-11-19T18:32:02Zen
dc.date.available2018-11-19T18:32:02Zen
dc.date.issued2012-01-10en
dc.description.abstractAt least three forms of signaling between pre- and postsynaptic partners are necessary during synapse formation. First, “targeting” signals instruct presynaptic axons to recognize and adhere to the correct portion of a postsynaptic target cell. Second, trans-synaptic “organizing” signals induce differentiation in their synaptic partner so that each side of the synapse is specialized for synaptic transmission. Finally, in many regions of the nervous system an excess of synapses are initially formed, therefore “refinement” signals must either stabilize or destabilize the synapse to reinforce or eliminate connections, respectively. Because of both their importance in processing visual information and their accessibility, retinogeniculate synapses have served as a model for studying synaptic development. Molecular signals that drive retinogeniculate “targeting” and “refinement” have been identified, however, little is known about what “organizing” cues are necessary for the differentiation of retinal axons into presynaptic terminals. To identify such “organizing” cues, we used microarray analysis to assess whether any target-derived “synaptic organizers” were enriched in the mouse dorsal lateral geniculate nucleus (dLGN) during retinogeniculate synapse formation. One candidate “organizing” molecule enriched in perinatal dLGN was FGF22, a secreted cue that induces the formation of excitatory nerve terminals in muscle, hippocampus, and cerebellum. In FGF22 knockout mice, the development of retinal terminals in dLGN was impaired. Thus, FGF22 is an important “organizing” cue for the timely development of retinogeniculate synapses.en
dc.description.sponsorshipThis work was supported by The Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust (Michael A. Fox), the VCU Presidential Research Initiative Program (PRIP) Award (Michael A. Fox), and the National Institutes of Health [NIH; EY021222 (Michael A. Fox); NS070005 (Hisashi Umemori)]. Microscopy was performed at the Virginia Commonwealth University Department of Anatomy and Neurobiology Microscopy Facility supported, in part, with funding from NIH–National Institute of Neurological Disorders and Stroke Center Core Grant 5P30 NS047463-02. We thank Dr. C. K. Chen for providing anti-melanopsin antibodies.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fnmol.2011.00061en
dc.identifier.urihttp://hdl.handle.net/10919/85883en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsynaptogenesisen
dc.subjectpresynaptic differentiationen
dc.subjectretinaen
dc.subjectretinal ganglion cellen
dc.subjectlateral geniculate nucleusen
dc.titleFibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleusen
dc.title.serialFrontiers in Molecular Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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