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Mathematical Models of E-Antigen Mediated Immune Tolerance and Activation following Prenatal HBV Infection

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dc.contributor.authorCiupe, Stanca M.en
dc.contributor.authorHews, Sarahen
dc.contributor.departmentMathematicsen
dc.date.accessioned2018-10-26T14:38:31Zen
dc.date.available2018-10-26T14:38:31Zen
dc.date.issued2012-07-02en
dc.description.abstractWe develop mathematical models for the role of hepatitis B e-antigen in creating immunological tolerance during hepatitis B virus infection and propose mechanisms for hepatitis B e-antigen clearance, subsequent emergence of a potent cellular immune response, and the effect of these on liver damage. We investigate the dynamics of virus-immune cells interactions, and derive parameter regimes that allow for viral persistence. We modify the model to account for mechanisms responsible for hepatitis B e-antigen loss, such as seroconversion and virus mutations that lead to emergence of cellular immune response to the mutant virus. Our models demonstrate that either seroconversion or mutations can induce immune activation and that instantaneous loss of e-antigen by either mechanism is associated with least liver damage and is therefore more beneficial for disease outcomes.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0039591en
dc.identifier.eissn1932-6203en
dc.identifier.issue7en
dc.identifier.othere39591en
dc.identifier.pmid22768303en
dc.identifier.urihttp://hdl.handle.net/10919/85535en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleMathematical Models of E-Antigen Mediated Immune Tolerance and Activation following Prenatal HBV Infectionen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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