A phylogenomic framework for charting the diversity and evolution of giant viruses

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dc.contributor.authorAylward, Frank O.en
dc.contributor.authorMoniruzzaman, Mohammaden
dc.contributor.authorHa, Anhen
dc.contributor.authorKoonin, Eugeneen
dc.date.accessioned2022-03-23T16:46:29Zen
dc.date.available2022-03-23T16:46:29Zen
dc.date.issued2021-10en
dc.description.abstractLarge DNA viruses of the phylum Nucleocytoviricota have recently emerged as important members of ecosystems around the globe that challenge traditional views of viral complexity. Numerous members of this phylum that cannot be classified within established families have recently been reported, and there is presently a strong need for a robust phylogenomic and taxonomic framework for these viruses. Here, we report a comprehensive phylogenomic analysis of the Nucleocytoviricota, present a set of giant virus orthologous groups (GVOGs) together with a benchmarked reference phylogeny, and delineate a hierarchical taxonomy within this phylum. We show that the majority of Nucleocytoviricota diversity can be partitioned into 6 orders, 32 families, and 344 genera, substantially expanding the number of currently recognized taxonomic ranks for these viruses. We integrate our results within a taxonomy that has been adopted for all viruses to establish a unifying framework for the study of Nucleocytoviricota diversity, evolution, and environmental distribution.</p>en
dc.description.notesThis work was supported by a Simons Early Career Award in Marine Microbial Ecology and Evolution to F.O.A, an the NSF (IIBR-1918271)award to F.O.A., and the Intramural Research Program of the National Institutes of Health (National Library of Medicine) for E.V.K. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.sponsorshipSimons Early Career Award in Marine Microbial Ecology and Evolution; NSFNational Science Foundation (NSF) [IIBR-1918271]; Intramural Research Program of the National Institutes of (National Library of Medicine) Healthen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pbio.3001430en
dc.identifier.eissn1545-7885en
dc.identifier.issn1544-9173en
dc.identifier.issue10en
dc.identifier.othere3001430en
dc.identifier.pmid34705818en
dc.identifier.urihttp://hdl.handle.net/10919/109434en
dc.identifier.volume19en
dc.language.isoenen
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.titleA phylogenomic framework for charting the diversity and evolution of giant virusesen
dc.title.serialPLOS Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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