Innate immune programing by endotoxin and its pathological consequences

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dc.contributor.authorMorris, Matthew C.en
dc.contributor.authorGilliam, Elizabeth A.en
dc.contributor.authorLi, Liwuen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2019-08-29T12:25:41Zen
dc.date.available2019-08-29T12:25:41Zen
dc.date.issued2015-01-06en
dc.description.abstractMonocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent studies suggest that dynamic programing of macrophages and monocytes may give rise to distinct “memory” states. Lipopolysaccharide (LPS), a classical pattern recognition molecule, dynamically programs innate immune responses. Emerging studies have revealed complex dynamics of cellular responses to LPS, with high doses causing acute, resolving inflammation, while lower doses are associated with low-grade and chronic non-resolving inflammation.These phenomena hint at dynamic complexities of intra-cellular signaling circuits downstream of theToll-like receptor 4 (TLR4). In this review, we examine pathological effects of varying LPS doses with respect to the dynamics of innate immune responses and key molecular regulatory circuits responsible for these effects.en
dc.description.sponsorshipWork in this laboratory is supported by NIH grant R01 HL115835 to Liwu Li.en
dc.format.extent8 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fimmu.2014.00680en
dc.identifier.urihttp://hdl.handle.net/10919/93289en
dc.identifier.volume5en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectinnate programingen
dc.subjectendotoxinen
dc.subjectpriming and toleranceen
dc.subjectsystems dynamicsen
dc.subjectacute and chronic inflammationen
dc.titleInnate immune programing by endotoxin and its pathological consequencesen
dc.title.serialFrontiers in Immunologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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