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Circadian dynamics in measures of cortical excitation and inhibition balance

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dc.contributor.authorChellappa, Sarah L.en
dc.contributor.authorGaggioni, Giuliaen
dc.contributor.authorLy, Julien Q. M.en
dc.contributor.authorPapachilleos, Soteriosen
dc.contributor.authorBorsu, Chloeen
dc.contributor.authorBrzozowski, Alexandreen
dc.contributor.authorRosanova, Marioen
dc.contributor.authorSarasso, Simoneen
dc.contributor.authorLuxen, Andreen
dc.contributor.authorMiddleton, Benitaen
dc.contributor.authorArcher, Simon N.en
dc.contributor.authorDijk, Derk-Janen
dc.contributor.authorMassimini, Marcelloen
dc.contributor.authorMaquet, Pierreen
dc.contributor.authorPhillips, Christopheen
dc.contributor.authorMoran, Rosalyn J.en
dc.contributor.authorVandewalle, Gillesen
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.date.accessioned2019-01-22T18:54:43Zen
dc.date.available2019-01-22T18:54:43Zen
dc.date.issued2016-09-21en
dc.description.abstractSeveral neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a 'final common pathway' of imbalanced excitation to inhibition within cortical networks. How the regulation of a cortical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established. Here we addressed this issue through the analyses of TMS-evoked responses recorded over a 29 h sleep deprivation protocol conducted in young and healthy volunteers. Spectral analyses of TMS-evoked responses in frontal cortex revealed non-linear changes in gamma band evoked oscillations, compatible with an influence of circadian timing on inhibitory interneuron activity. In silico inferences of cell-to-cell excitatory and inhibitory connectivity and GABA/Glutamate receptor time constant based on neural mass modeling within the Dynamic causal modeling framework, further suggested excitation/inhibition balance was under a strong circadian influence. These results indicate that circadian changes in EEG spectral properties, in measure of excitatory/inhibitory connectivity and in GABA/glutamate receptor function could support the maintenance of cognitive performance during a normal waking day, but also during overnight wakefulness. More generally, these findings demonstrate a slow daily regulation of cortical excitation/inhibition balance, which depends on circadian-timing and prior sleep-wake history.en
dc.description.notesThis was supported by the Fonds National de la Recherche Scientifique (FRS-FNRS, Belgium; grant number: 3.4516.11F), University of Liege (ULg) special funds, Wallonia Brussels International (WBI), AXA Foundation, Fondation Medicale Reine Elisabeth (FMRE, Belgium), European Regional Development Fund (ERDF; grant: Radiomed project), Walloon excellence in life sciences and biotechnology (grant number: WELBIO-CR-2010-06E, Belgium), Wallonia/Brussels Federation "Action de Recherche Concertee" (grant number: ARC 09/14-03) and a Royal Society Wolfson Research Merit Award (grant number: WM120086). We thank Annick Claes, Dorothee Coppieters, Christian Degueldre, Karl Friston, Olivia Gosserie, Patrick Hawotte, Brigitte Herbillon, Mathieu Jaspar, Steven Laureys, Benjamin Lauricella, Vincenzo Muto, Christelle Meyer, and all our undergraduate student helpers.en
dc.description.sponsorshipFonds National de la Recherche Scientifique (FRS-FNRS, Belgium) [3.4516.11F]; University of Liege (ULg) special funds; Wallonia Brussels International (WBI); AXA Foundation; Fondation Medicale Reine Elisabeth (FMRE, Belgium); European Regional Development Fund (ERDF); Walloon excellence in life sciences and biotechnology (Belgium) [WELBIO-CR-2010-06E]; Wallonia/Brussels Federation "Action de Recherche Concertee" [ARC 09/14-03]; Royal Society Wolfson Research Merit Award [WM120086]en
dc.format.extent13en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/srep33661en
dc.identifier.issn2045-2322en
dc.identifier.other33661en
dc.identifier.pmid27651114en
dc.identifier.urihttp://hdl.handle.net/10919/86834en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjecttranscranial magnetic stimulationen
dc.subjectsynaptic plasticityen
dc.subjectbrain responsesen
dc.subjecthuman sleepen
dc.subjecthomeostasisen
dc.subjectexcitabilityen
dc.subjectinventoryen
dc.subjectcortexen
dc.subjectphaseen
dc.subjecteegen
dc.titleCircadian dynamics in measures of cortical excitation and inhibition balanceen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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