Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease

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dc.contributor.authorMason, Mike J.en
dc.contributor.authorSchinke, Carolinaen
dc.contributor.authorEng, Christine L. P.en
dc.contributor.authorTowfic, Fadien
dc.contributor.authorGruber, Freden
dc.contributor.authorDervan, Andrewen
dc.contributor.authorWhite, Brian S.en
dc.contributor.authorPratapa, Adityaen
dc.contributor.authorGuan, Yuanfangen
dc.contributor.authorChen, Hongjieen
dc.contributor.authorCui, Yien
dc.contributor.authorLi, Bailiangen
dc.contributor.authorYu, Thomasen
dc.contributor.authorNeto, Elias Chaibuben
dc.contributor.authorMavrommatis, Konstantinosen
dc.contributor.authorOrtiz, Mariaen
dc.contributor.authorLyzogubov, Valeriyen
dc.contributor.authorBisht, Kamleshen
dc.contributor.authorDai, Hongyue Y.en
dc.contributor.authorSchmitz, Franken
dc.contributor.authorFlynt, Erinen
dc.contributor.authorRozelle, Danen
dc.contributor.authorDanziger, Samuel A.en
dc.contributor.authorRatushny, Alexanderen
dc.contributor.authorDalton, William S.en
dc.contributor.authorGoldschmidt, Hartmuten
dc.contributor.authorAvet-Loiseau, Herveen
dc.contributor.authorSamur, Mehmeten
dc.contributor.authorHayete, Borisen
dc.contributor.authorSonneveld, Pieteren
dc.contributor.authorShain, Kenneth H.en
dc.contributor.authorMunshi, Nikhilen
dc.contributor.authorAuclair, Danielen
dc.contributor.authorHose, Dirken
dc.contributor.authorMorgan, Garethen
dc.contributor.authorTrotter, Matthewen
dc.contributor.authorBassett, Douglasen
dc.contributor.authorGoke, Jonathanen
dc.contributor.authorWalker, Brian A.en
dc.contributor.authorThakurta, Anjanen
dc.contributor.authorGuinney, Justinen
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2021-01-07T18:13:52Zen
dc.date.available2021-01-07T18:13:52Zen
dc.date.issued2020-02-14en
dc.description.abstractWhile the past decade has seen meaningful improvements in clinical outcomes for multiple myeloma patients, a subset of patients does not benefit from current therapeutics for unclear reasons. Many gene expression-based models of risk have been developed, but each model uses a different combination of genes and often involves assaying many genes making them difficult to implement. We organized the Multiple Myeloma DREAM Challenge, a crowdsourced effort to develop models of rapid progression in newly diagnosed myeloma patients and to benchmark these against previously published models. This effort lead to more robust predictors and found that incorporating specific demographic and clinical features improved gene expression-based models of high risk. Furthermore, post-challenge analysis identified a novel expression-based risk marker, PHF19, which has recently been found to have an important biological role in multiple myeloma. Lastly, we show that a simple four feature predictor composed of age, ISS, and expression of PHF19 and MMSET performs similarly to more complex models with many more gene expression features included.en
dc.description.notesWork completed by CS was funded by NCATS grant, KL2TR000063. A complete list of the members of the Multiple Myeloma DREAM Consortium appears in the supplement text.en
dc.description.sponsorshipNCATSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [KL2TR000063]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41375-020-0742-zen
dc.identifier.eissn1476-5551en
dc.identifier.issn0887-6924en
dc.identifier.issue7en
dc.identifier.pmid32060406en
dc.identifier.urihttp://hdl.handle.net/10919/101772en
dc.identifier.volume34en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleMultiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive diseaseen
dc.title.serialLeukemiaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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