Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis

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dc.contributor.authorHeaven, Michael R.en
dc.contributor.authorHerren, Anthony W.en
dc.contributor.authorFlint, Daniel L.en
dc.contributor.authorPacheco, Natasha L.en
dc.contributor.authorLi, Jiangtaoen
dc.contributor.authorTang, Aliceen
dc.contributor.authorKhan, Fatimaen
dc.contributor.authorGoldman, James E.en
dc.contributor.authorPhinney, Brett S.en
dc.contributor.authorOlsen, Michelle L.en
dc.date.accessioned2022-07-18T14:11:00Zen
dc.date.available2022-07-18T14:11:00Zen
dc.date.issued2021-11-20en
dc.description.abstractThe article contains the first whole brain proteomic survey from a mouse model of Alexander disease (AxD). Several novel findings include activation of the PPAR signaling pathway, which has been reported to be protective in models of amyotrophic lateral sclerosis (ALS). Another finding related to the gliosis phenotype in AxD mice was the upregulation of fatty acid binding protein 7 (FABP7), which induces an NF-κB inflammatory response and counteracts the antiinflammatory effects of PPAR signaling.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.mcpro.2021.100180en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/111277en
dc.identifier.volume21en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleMetabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosisen
dc.title.serialMolecular & Cellular Proteomicsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, School of Neuroscience
Destination Area: Adaptive Brain and Behavior (ABB)