Dysgerminoma Masquerading as Gestational Trophoblastic Neoplasia

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Background: Persistent elevation in beta-human chorionic gonadotropin (β-hCG) following a pregnancy is concerning for gestational trophoblastic neoplasia (GTN). However, the differential diagnosis should remain broad during the evaluation process. Case: A 34-year-old G3P3 presented with elevated β-hCG four months after cesarean delivery with bilateral tubal ligation. The patient was treated with methotrexate for a presumed new ectopic pregnancy. Due to persistent β-hCG elevation, she received actinomycin-D for GTN treatment. After completing chemotherapy, her β-hCG increased. The patient underwent a laparoscopic hysterectomy with unplanned left oophorectomy due to its nodular appearance at the time of surgery. Pathology confirmed a dysgerminoma of the ovary and benign uterus. Conclusion: Although dysgerminomas are uncommon, they should be considered when β-hCG levels remain elevated despite therapies for more common pathologies.




Conner Blackwell, Shian McLeish, David Iglesias, and Shannon D. Armbruster, “Dysgerminoma Masquerading as Gestational Trophoblastic Neoplasia,” Case Reports in Obstetrics and Gynecology, vol. 2023, Article ID 1901858, 4 pages, 2023. doi:10.1155/2023/1901858