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Mathematical Modeling for the Pathogenesis of Alzheimer's Disease

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dc.contributor.authorPuri, Ishwar K.en
dc.contributor.authorLi, Liwuen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2018-11-09T20:22:02Zen
dc.date.available2018-11-09T20:22:02Zen
dc.date.issued2010-12-14en
dc.description.abstractDespite extensive research, the pathogenesis of neurodegenerative Alzheimer's disease (AD) still eludes our comprehension. This is largely due to complex and dynamic cross-talks that occur among multiple cell types throughout the aging process. We present a mathematical model that helps define critical components of AD pathogenesis based on differential rate equations that represent the known cross-talks involving microglia, astroglia, neurons, and amyloid-β (Aβ). We demonstrate that the inflammatory activation of microglia serves as a key node for progressive neurodegeneration. Our analysis reveals that targeting microglia may hold potential promise in the prevention and treatment of AD.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0015176en
dc.identifier.eissn1932-6203en
dc.identifier.issue12en
dc.identifier.othere15176en
dc.identifier.pmid21179474en
dc.identifier.urihttp://hdl.handle.net/10919/85814en
dc.identifier.volume5en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleMathematical Modeling for the Pathogenesis of Alzheimer's Diseaseen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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