Tandemly Arrayed Genes in Vertebrate Genomes

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dc.contributor.authorPan, Dengen
dc.contributor.authorZhang, Liqingen
dc.contributor.departmentComputer Scienceen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2017-09-18T10:03:22Zen
dc.date.available2017-09-18T10:03:22Zen
dc.date.issued2008-09-21en
dc.date.updated2017-09-18T10:03:22Zen
dc.description.abstractTandemly arrayed genes (TAGs) are duplicated genes that are linked as neighbors on a chromosome, many of which have important physiological and biochemical functions. Here we performed a survey of these genes in 11 available vertebrate genomes. TAGs account for an average of about 14% of all genes in these vertebrate genomes, and about 25% of all duplications. The majority of TAGs (72–94%) have parallel transcription orientation (i.e., they are encoded on the same strand) in contrast to the genome, which has about 50% of its genes in parallel transcription orientation. The majority of tandem arrays have only two members. In all species, the proportion of genes that belong to TAGs tends to be higher in large gene families than in small ones; together with our recent finding that tandem duplication played a more important role than retroposition in large families, this fact suggests that among all types of duplication mechanisms, tandem duplication is the predominant mechanism of duplication, especially in large families. Finally, several species have a higher proportion of large tandem arrays that are species-specific than random expectation.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDeng Pan and Liqing Zhang, “Tandemly Arrayed Genes in Vertebrate Genomes,” Comparative and Functional Genomics, vol. 2008, Article ID 545269, 11 pages, 2008. doi:10.1155/2008/545269en
dc.identifier.doihttps://doi.org/10.1155/2008/545269en
dc.identifier.urihttp://hdl.handle.net/10919/79064en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2008 Deng Pan and Liqing Zhang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleTandemly Arrayed Genes in Vertebrate Genomesen
dc.title.serialComparative and Functional Genomicsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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