Target-Derived Matricryptins Organize Cerebellar Synapse Formation through _3_1 Integrins

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dc.contributor.authorSu, Jianminen
dc.contributor.authorStenbjorn, Renee S.en
dc.contributor.authorGorse, Karenen
dc.contributor.authorSu, Kaiwenen
dc.contributor.authorHauser, Kurt F.en
dc.contributor.authorRicard-Blum, Sylvieen
dc.contributor.authorPihlajaniemi, Tainaen
dc.contributor.authorFox, Michael A.en
dc.date.accessioned2019-06-03T21:03:13Zen
dc.date.available2019-06-03T21:03:13Zen
dc.date.issued2012en
dc.description.abstractTrans-synaptic organizing cues must be passed between synaptic partners for synapses to properly form. Much of our understanding of this process stems from studies at the neuromuscular junction, where target-derived growth factors, extracellular matrix (ECM) molecules, and matricryptins (proteolytically released fragments of ECM molecules) are all essential for the formation and maintenance of motor nerve terminals. While growth factors and ECM molecules also contribute to the formation of brain synapses, it remains unclear whether synaptic roles exist for matricryptins in the mammalian brain. We report that collagen XVIII and its matricryptin endostatin are generated by cerebellar Purkinje cells and are necessary for the organization of climbing fiber terminals in these neurons. Moreover, endostatin is sufficient to induce climbing fiber terminal formation in vitro by binding and signaling through _3_1 integrins. Taken together, these studies reveal roles for both matricryptins and integrins in the organization of brain synapses.en
dc.description.sponsorshipA.D. Williams Granten
dc.description.sponsorshipNational Institutes of Health (NIH) Grant EY021222en
dc.description.sponsorshipNIH Core Grant (NS047463)en
dc.format.extent8 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2012.07.001en
dc.identifier.urihttp://hdl.handle.net/10919/89731en
dc.identifier.volume2en
dc.language.isoenen
dc.publisherCellen
dc.rightsCreative Commons Attribution 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.titleTarget-Derived Matricryptins Organize Cerebellar Synapse Formation through _3_1 Integrinsen
dc.title.serialCell Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Fralin Biomedical Research Institute at VTC
Destination Area: Adaptive Brain and Behavior (ABB)