Sex differences in depression: An immunological perspective

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dc.contributor.authorKropp, Dawson R.en
dc.contributor.authorHodes, Georgia E.en
dc.date.accessioned2023-10-11T13:20:26Zen
dc.date.available2023-10-11T13:20:26Zen
dc.date.issued2023-05en
dc.description.abstractDepression is a heterogenous disorder with symptoms that present differently across individuals. In a subset of people depression is associated with alterations of the immune system that may contribute to disorder onset and symptomology. Women are twice as likely to develop depression and on average have a more sensitive adaptive and innate immune system when compared to men. Sex differences in pattern recognition receptors (PRRs), release of damage-associated molecular patterns (DAMPs), cell populations, and circulating cytokines play a critical role in inflammation onset. Sex differences in innate and adaptive immunity change the response of and repair to damage caused by dangerous pathogens or molecules in the body. This article reviews the evidence for sex specific immune responses that contribute to the sex differences in symptoms of depression that may account for the higher rate of depression in women.en
dc.description.notesAcknowledgements This work was supported by NIMH R56MH124930 (GEH) . Figure was created using biorender.com .en
dc.description.sponsorshipNIMH [R56MH124930]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.brainresbull.2023.02.016en
dc.identifier.eissn1873-2747en
dc.identifier.issn0361-9230en
dc.identifier.pmid36863664en
dc.identifier.urihttp://hdl.handle.net/10919/116446en
dc.identifier.volume196en
dc.language.isoenen
dc.publisherPergamon-Elsevieren
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectStressen
dc.subjectSexen
dc.subjectDepressionen
dc.subjectMDDen
dc.subjectImmuneen
dc.titleSex differences in depression: An immunological perspectiveen
dc.title.serialBrain Research Bulletinen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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