Sirt1 coordinates with ERα to regulate autophagy and adiposity

Simple item page
dc.contributor.authorTao, Zhipengen
dc.contributor.authorShi, Liminen
dc.contributor.authorParke, Janeen
dc.contributor.authorZheng, Louiseen
dc.contributor.authorGu, Weien
dc.contributor.authorDong, X. Charlieen
dc.contributor.authorLiu, Dongminen
dc.contributor.authorWang, Zongweien
dc.contributor.authorOlumi, Aria F.en
dc.contributor.authorCheng, Zhiyongen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2021-04-22T12:22:46Zen
dc.date.available2021-04-22T12:22:46Zen
dc.date.issued2021-03-15en
dc.description.abstractSex difference in adiposity has long been recognized but the mechanism remains incompletely understood. Previous studies suggested that adiposity was regulated by autophagy in response to energy status change. Here, we show that the energy sensor Sirt1 mediates sex difference in adiposity by regulating autophagy and adipogenesis in partnership with estrogen receptor α (ERα). Autophagy and adipogenesis were suppressed by Sirt1 activation or overexpression, which was associated with reduced sex difference in adiposity. Mechanistically, Sirt1 deacetylated and activated AKT and STAT3, resulting in suppression of autophagy and adipogenesis via mTOR-ULK1 and p55 cascades. ERα induced Sirt1 expression and inhibited autophagy in adipocytes, while silencing Sirt1 reversed the effects of ERα on autophagy and promoted adipogenesis. Moreover, Sirt1 deacetylated ERα, which constituted a positive feedback loop in the regulation of autophagy and adiposity. Our results revealed a new mechanism of Sirt1 regulating autophagy in adipocytes and shed light on sex difference in adiposity.en
dc.description.notesThis work was supported in part by the American Heart Association Grant (18TPA34230082 to Z.C.), and the USDA National Institute of Food and Agriculture Grant (1020373 to Z.C).en
dc.description.sponsorshipAmerican Heart Association GrantAmerican Heart Association [18TPA34230082]; USDA National Institute of Food and Agriculture Grant [1020373]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41420-021-00438-8en
dc.identifier.eissn2058-7716en
dc.identifier.issue1en
dc.identifier.other53en
dc.identifier.pmid33723227en
dc.identifier.urihttp://hdl.handle.net/10919/103078en
dc.identifier.volume7en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleSirt1 coordinates with ERα to regulate autophagy and adiposityen
dc.title.alternativeSirt1 coordinates with ER alpha to regulate autophagy and adiposityen
dc.title.serialCell Death Discoveryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41420-021-00438-8.pdf
Size:
2.23 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Scholarly Works, Human Nutrition, Foods, and Exercise