CEACAM1 Activation by CbpF-Expressing E. coli

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dc.contributor.authorShhadeh, Amjaden
dc.contributor.authorGalaski, Johannaen
dc.contributor.authorAlon-Maimon, Tamaren
dc.contributor.authorFahoum, Jamalen
dc.contributor.authorWiener, Reuvenen
dc.contributor.authorSlade, Daniel J.en
dc.contributor.authorMandelboim, Oferen
dc.contributor.authorBachrach, Giladen
dc.date.accessioned2022-04-06T14:34:58Zen
dc.date.available2022-04-06T14:34:58Zen
dc.date.issued2021-07-29en
dc.description.abstractRecent studies on the oral, anaerobic, gram-negative bacterium Fusobacterium nucleatum revealed its presence and involvement in colorectal, esophageal and breast cancer. We previously demonstrated that F. nucleatum binds and activates the human inhibitory receptors TIGIT and CEACAM1 leading to inhibition of T and NK cell anti-tumor immunity. CEACAM1 was found to be bound and activated by the fusobacterial trimeric autotransporter adhesin CbpF. Here we report the generation of a recombinant E. coli expressing full-length CbpF that efficiently binds and activates CEACAM1.</p>en
dc.description.notesThis work was supported by the Israel Cancer Research Fund Project grant (GB), the Israel Science Foundation Moked grant and the Israel Ministry of Science and Technology Personalized Medicine grant (GB and OM). AS is supported by the Planning and Budgeting Committee of the Israeli Council for Higher Education. JG is supported by the German Research Foundation (DFG) with a postdoctoral research fellowship.en
dc.description.sponsorshipIsrael Cancer Research Fund Project; Israel Science Foundation Moked grant; Israel Ministry of Science and Technology Personalized Medicine grant; Planning and Budgeting Committee of the Israeli Council for Higher Education; German Research Foundation (DFG)German Research Foundation (DFG)en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fcimb.2021.699015en
dc.identifier.issn2235-2988en
dc.identifier.other699015en
dc.identifier.pmid34395310en
dc.identifier.urihttp://hdl.handle.net/10919/109574en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectF. nucleatumen
dc.subjectCbpFen
dc.subjecttrimeric autotransporter adhesinen
dc.subjectCEACAM1en
dc.subjectNK cellsen
dc.titleCEACAM1 Activation by CbpF-Expressing E. colien
dc.title.serialFrontiers in Cellular and Infection Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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