Sustaining Transmission in Different Host Species: The Emblematic Case of Sarcoptes scabiei

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dc.contributor.authorBrowne, Elizabethen
dc.contributor.authorDriessen, Michael M.en
dc.contributor.authorCross, Paul C.en
dc.contributor.authorEscobar, Luis E.en
dc.contributor.authorFoley, Janeten
dc.contributor.authorLopez-Olvera, Jorge R.en
dc.contributor.authorNiedringhaus, Kevin D.en
dc.contributor.authorRossi, Lucaen
dc.contributor.authorCarver, Scotten
dc.date.accessioned2022-05-03T12:32:48Zen
dc.date.available2022-05-03T12:32:48Zen
dc.date.issued2022-02-03en
dc.description.abstractSome pathogens sustain transmission in multiple different host species, but how this epidemiologically important feat is achieved remains enigmatic. Sarcoptes scabiei is among the most host generalist and successful of mammalian parasites. We synthesize pathogen and host traits that mediate sustained transmission and present cases illustrating three transmission mechanisms (direct, indirect, and combined). The pathogen traits that explain the success of S. scabiei include immune response modulation, on-host movement capacity, off-host seeking behaviors, and environmental persistence. Sociality and host density appear to be key for hosts in which direct transmission dominates, whereas in solitary hosts, the use of shared environments is important for indirect transmission. In social den-using species, combined direct and indirect transmission appears likely. Empirical research rarely considers the mechanisms enabling S. scabiei to become endemic in host species-more often focusing on outbreaks. Our review may illuminate parasites' adaptation strategies to sustain transmission through varied mechanisms across host species.en
dc.description.adminPublic domain – authored by a U.S. government employeeen
dc.description.notesWe thank Chris Burridge and Geoff While for feedback and assessment of an early draft. This work was supported by an Australian Research Council Link Project grant (no. LP180101251) to SC and the Tasmanian Government Honours Scholarship in Wildlife Conservation awarded to EB by the Department of Primary Industries, Parks, Water, and Environment. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the US government.en
dc.description.sponsorshipAustralian Research CouncilAustralian Research Council [LP180101251]; Tasmanian Government Honours Scholarship in Wildlife Conservation by Department of Primary Industries, Parks, Water, and Environmenten
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/biosci/biab106en
dc.identifier.eissn1525-3244en
dc.identifier.issn0006-3568en
dc.identifier.issue2en
dc.identifier.urihttp://hdl.handle.net/10919/109790en
dc.identifier.volume72en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rightsPublic Domain (U.S.)en
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/en
dc.subjectsarcoptic mangeen
dc.subjectscabiesen
dc.subjecthost pathogen traitsen
dc.subjectdisease dynamicsen
dc.subjectpathogen persistenceen
dc.subjectendemic transmissionen
dc.titleSustaining Transmission in Different Host Species: The Emblematic Case of Sarcoptes scabieien
dc.title.serialBioscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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