Mathematical model of the cell division cycle of fission yeast

dc.contributorVirginia Techen
dc.contributor.authorNovak, Belaen
dc.contributor.authorPataki, Z.en
dc.contributor.authorCiliberto, Andreaen
dc.contributor.authorTyson, John J.en
dc.contributor.departmentBiological Sciencesen
dc.date.accessed2014-03-20en
dc.date.accessioned2014-04-09T18:12:22Zen
dc.date.available2014-04-09T18:12:22Zen
dc.date.issued2001-03en
dc.description.abstractMuch is known about the genes and proteins controlling the cell cycle of fission yeast. Can these molecular components be spun together into a consistent mechanism that accounts for the observed behavior of growth and division in fission yeast cells? To answer this question, we propose a mechanism for the control system, convert it into a set of 14 differential and algebraic equations, study these equations by numerical simulation and bifurcation theory, and compare our results to the physiology of wild-type and mutant cells. In wild-type cells, progress through the cell cycle (G1 -->S --> G2 -->M) is related to cyclic progression around a hysteresis loop, driven by cell growth and chromosome alignment on the metaphase plate. However, the control system operates much differently in double-mutant cells, wee1(-) cdc25 Delta, which are defective in progress through the latter half of the cell cycle (G2 and M phases). These cells exhibit "quantized" cycles (interdivision times clustering around 90, 160, and 230 min). We show that these quantized cycles are associated with a supercritical Hopf bifurcation in the mechanism, when the wee1 and cdc25 genes are disabled. (C) 2001 American Institute of Physics.en
dc.description.sponsorshipHoward Hughes Medical Institute 75195-542501en
dc.description.sponsorshipHungarian Scientific Research Fund OTKA T 032015en
dc.description.sponsorshipNSF DBI-9724085, MCB-0078920en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNovak, B.; Pataki, Z.; Ciliberto, A.; Tyson, J. J., "mathematical model of the cell division cycle of fission yeast," Chaos 11, 277 (2001); http://dx.doi.org/10.1063/1.1345725en
dc.identifier.doihttps://doi.org/10.1063/1.1345725en
dc.identifier.issn1054-1500en
dc.identifier.urihttp://hdl.handle.net/10919/47057en
dc.identifier.urlhttp://scitation.aip.org/content/aip/journal/chaos/11/1/10.1063/1.1345725en
dc.language.isoenen
dc.publisherAIP Publishingen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectanaphase-promoting complexen
dc.subjectp25(rum1) cdk inhibitoren
dc.subjects-phaseen
dc.subjectschizosaccharomyces-pombeen
dc.subjectmolecular-modelen
dc.subjectmitotic induceren
dc.subjectg1 phaseen
dc.subjectmitosisen
dc.subjectkinaseen
dc.subjectcdc2en
dc.titleMathematical model of the cell division cycle of fission yeasten
dc.title.serialChaosen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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