Interstitial fluid flow in cancer: implications for disease progression and treatment

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dc.contributor.authorMunson, Jennifer M.en
dc.contributor.authorShieh, Adrian C.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2018-07-27T15:23:49Zen
dc.date.available2018-07-27T15:23:49Zen
dc.date.issued2014-08-19en
dc.description.abstractAs cancer progresses, a dynamic microenvironment develops that creates and responds to cellular and biophysical cues. Increased intratumoral pressure and corresponding increases in interstitial flow from the tumor bulk to the healthy stroma is an observational hallmark of progressing cancers. Until recently, the role of interstitial flow was thought to be mostly passive in the transport and dissemination of cancer cells to metastatic sites. With research spanning the past decade, we have seen that interstitial flow has a promigratory effect on cancer cell invasion in multiple cancer types. This invasion is one mechanism by which cancers can resist therapeutics and recur, but the role of interstitial flow in cancer therapy is limited to the understanding of transport of therapeutics. Here we outline the current understanding of the role of interstitial flow in cancer and the tumor microenvironment through cancer progression and therapy. We also discuss the current role of fluid flow in the treatment of cancer, including drug transport and therapeutic strategies. By stating the current understanding of interstitial flow in cancer progression, we can begin exploring its role in therapeutic failure and treatment resistance.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.2147/CMAR.S65444en
dc.identifier.urihttp://hdl.handle.net/10919/84423en
dc.identifier.urlhttps://www.dovepress.com/interstitial-fluid-flow-in-cancer-implications-for-disease-progression-peer-reviewed-article-CMARen
dc.identifier.volume6en
dc.language.isoen_USen
dc.publisherDove Medical Pressen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/en
dc.subjectTumor microenvironmenten
dc.subjectInterstitial flowen
dc.subjectTherapeuticsen
dc.subjectInvasionen
dc.titleInterstitial fluid flow in cancer: implications for disease progression and treatmenten
dc.title.serialCancer Management and Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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