Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter

dc.contributor.assigneeThe American Red Crossen
dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.assigneeThe United States of America as represented by the Department of Health and Human Servicesen
dc.contributor.inventorDrohan, William N.en
dc.contributor.inventorVelander, William H.en
dc.contributor.inventorLubon, Henryken
dc.contributor.inventorHennighausen, Lotharen
dc.date.accessed2016-08-19en
dc.date.accessioned2016-08-24T17:54:13Zen
dc.date.available2016-08-24T17:54:13Zen
dc.date.filed1999-05-28en
dc.date.issued2001-07-17en
dc.description.abstractAn isolated DNA sequence which regulates the expression of a heterologous gene composed of a mouse whey acidic protein promoter having a length of greater than about 2.4 kb extending upstream from the unique KpnI site in the mouse whey acidic protein gene is disclosed. Specifically a mouse whey acidic protein promoter of about 4.1-4.2 kb in length extending upstream from the unique KpnI site is preferred. This mouse whey acid protein promoter is operably linked to a DNA sequence encoding a heterologous polypeptide and used to prepare transgenic non-human mammals expressing the heterologous polypeptide in their milk. Particularly efficient expression of both cDNAs and genomic DNAs encoding heterologous polypeptides was obtained in transgenic non-human mammals using this promoter, known as the long whey acidic protein promoter.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber9321831en
dc.identifier.patentnumber6262336en
dc.identifier.urihttp://hdl.handle.net/10919/72432en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/36/623/062/0.pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA01K67/0275en
dc.subject.cpcA01K2207/15en
dc.subject.cpcA01K2217/00en
dc.subject.cpcA01K2217/05en
dc.subject.cpcA01K2227/10en
dc.subject.cpcA01K2227/105en
dc.subject.cpcA01K2227/108en
dc.subject.cpcA01K2267/01en
dc.subject.cpcA61K38/00en
dc.subject.cpcC07K14/75en
dc.subject.cpcC07K2319/00en
dc.subject.cpcC07K2319/02en
dc.subject.cpcC12N15/8509en
dc.subject.cpcC12N9/6464en
dc.subject.cpcC12Y304/21069en
dc.subject.cpcC12N2830/008en
dc.subject.uspc536/24.1en
dc.subject.uspcother800/14en
dc.subject.uspcother800/7en
dc.subject.uspcother800/15en
dc.subject.uspcother800/16en
dc.subject.uspcother800/17en
dc.subject.uspcother800/18en
dc.titleExpression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoteren
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen
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