PIG-the pathogen interaction gateway

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dc.contributor.authorDriscoll, Timothyen
dc.contributor.authorDyer, Matthew D.en
dc.contributor.authorMurali, T. M.en
dc.contributor.authorSobral, Brunoen
dc.contributor.departmentComputer Scienceen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2019-04-18T14:46:57Zen
dc.date.available2019-04-18T14:46:57Zen
dc.date.issued2009-01en
dc.description.abstractProtein-protein interactions (PPIs) play a vital role in initiating infection in a number of pathogens. Identifying which interactions allow a pathogen to infect its host can help us to understand methods of pathogenesis and provide potential targets for therapeutics. Public resources for studying host pathogen systems, in particular PPIs, are scarce. To facilitate the study of host-pathogen PPIs, we have collected and integrated host-pathogen PPI (HP-PPI) data from a number of public resources to create the Pathogen Interaction Gateway (PIG). PIG provides a text based search and a BLAST interface for searching the HP-PPI data. Each entry in PIG includes information such as the functional annotations and the domains present in the interacting proteins. PIG provides links to external databases to allow for easy navigation among the various websites. Additionally, PIG includes a tool for visualizing a single HP-PPI network or two HP-PPI networks. PIG can be accessed at http://pig.vbi.vt.edu.en
dc.description.notesNational Institute of Allergy and Infectious Diseases grant HHSN26620040035C. Funding for open access charge: NIH grant.en
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases [HHSN26620040035C]; NIHen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/nar/gkn799en
dc.identifier.eissn1362-4962en
dc.identifier.issn0305-1048en
dc.identifier.pmid18984614en
dc.identifier.urihttp://hdl.handle.net/10919/89032en
dc.identifier.volume37en
dc.language.isoen_USen
dc.rightsCreative Commons Attribution-NonCommercial 2.0 Genericen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/en
dc.subjectmolecular interaction databaseen
dc.subjectproteinen
dc.subjectresourceen
dc.subjectupdateen
dc.titlePIG-the pathogen interaction gatewayen
dc.title.serialNucleic Acids Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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