Long-term recovery from opioid use disorder: recovery subgroups, transition states and their association with substance use, treatment and quality of life

Simple item page
dc.contributor.authorCraft, William H.en
dc.contributor.authorShin, Hwasooen
dc.contributor.authorTegge, Allison N.en
dc.contributor.authorKeith, Diana R.en
dc.contributor.authorAthamneh, Liqa N.en
dc.contributor.authorStein, Jeffrey S.en
dc.contributor.authorFerreira, Marco A. R.en
dc.contributor.authorChilcoat, Howard D.en
dc.contributor.authorLe Moigne, Anneen
dc.contributor.authorDeVeaugh-Geiss, Angelaen
dc.contributor.authorBickel, Warren K.en
dc.date.accessioned2023-03-29T13:25:24Zen
dc.date.available2023-03-29T13:25:24Zen
dc.date.issued2022-12en
dc.description.abstractBackground and AimsLimited information exists regarding individual subgroups of recovery from opioid use disorder (OUD) following treatment and how these subgroups may relate to recovery trajectories. We used multi-dimensional criteria to identify OUD recovery subgroups and longitudinal transitions across subgroups. Design, Setting and ParticipantsIn a national longitudinal observational study in the United States, individuals who previously participated in a clinical trial for subcutaneous buprenorphine injections for treatment of OUD were enrolled and followed for an average of 4.2 years after participation in the clinical trial. MeasurementsWe identified recovery subgroups based on psychosocial outcomes including depression, opioid withdrawal and pain. We compared opioid use, treatment utilization and quality of life among these subgroups. FindingsThree dimensions of the recovery process were identified: depression, opioid withdrawal and pain. Using these three dimensions, participants were classified into four recovery subgroups: high-functioning (minimal depression, mild withdrawal and no/mild pain), pain/physical health (minimal depression, mild withdrawal and moderate pain), depression (moderate depression, mild withdrawal and mild/moderate pain) and low-functioning (moderate/severe withdrawal, moderate depression and moderate/severe pain). Significant differences among subgroups were observed for DSM-5 criteria (P < 0.001) and remission status (P < 0.001), as well as with opioid use (P < 0.001), treatment utilization (P < 0.001) and quality of life domains (physical health, psychological, environment and social relationships; Ps < 0.001, Cohen's fs >= 0.62). Recovery subgroup assignments were dynamic, with individuals transitioning across subgroups during the observational period. Moreover, the initial recovery subgroup assignment was minimally predictive of long-term outcomes. ConclusionsThere appear to be four distinct subgroups among individuals in recovery from OUD. Recovery subgroup assignments are dynamic and predictive of contemporaneous, but not long-term, substance use, substance use treatment utilization or quality of life outcomes.en
dc.description.notesThis study was funded by Indivior, Inc., North Chesterfield, VA, USA.en
dc.description.sponsorshipIndivior, Incen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/add.16115en
dc.identifier.eissn1360-0443en
dc.identifier.pmid36524904en
dc.identifier.urihttp://hdl.handle.net/10919/114223en
dc.language.isoenen
dc.publisherWileyen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMOUDen
dc.subjectopioid use disorderen
dc.subjectpersonalized medicineen
dc.subjectpsychosocial factorsen
dc.subjectquality of lifeen
dc.subjectrecoveryen
dc.subjectrecovery dimensionsen
dc.subjectrecovery trajectoriesen
dc.subjectsubgroupen
dc.subjecttreatmenten
dc.titleLong-term recovery from opioid use disorder: recovery subgroups, transition states and their association with substance use, treatment and quality of lifeen
dc.title.serialAddictionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CraftLongterm2023.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Scholarly Works, Fralin Biomedical Research Institute at VTC
Scholarly Works, Statistics