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Investigation into Polyurethane at Varying Dose Rates of Ionizing Radiation for Clinical Application

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dc.contributor.authorCooke, Shelley L.en
dc.contributor.authorWhittington, Abby R.en
dc.contributor.departmentChemical Engineeringen
dc.contributor.departmentMaterials Science and Engineering (MSE)en
dc.date.accessioned2018-10-08T12:47:45Zen
dc.date.available2018-10-08T12:47:45Zen
dc.date.issued2018-10-01en
dc.date.updated2018-10-07T07:02:15Zen
dc.description.abstractPolyurethanes (PUs) are commonly used materials for medical devices. These devices are exposed repeatedly to radiation when patients undergo radiotherapy treatments. It has been found that peripherally inserted central catheters (PICCs) and central venous catheters (CVCs) fail at an increased rate (14.7% and 8.8%, respectively) when radiated. Currently, little research is available on increased failure seen in conjunction with radiation, but complex in vivo environments within a human patient make it difficult to isolate effects of individual variables. This research investigated effects of radiation in an aqueous environment to determine whether radiation combined with a mimicked in vivo environment is sufficient to change PU devices. The following dose rates were used in this study: 3.2 Gy·min−1, 4.5 Gy·min−1, 44 Gy·min−1, and 833 Gy·min−1. Samples were characterized in four main ways: cellular response, physical changes, chemical changes, and mechanical changes. Results reveal normal cellular response at all dose rates, indicating dose rate does not alter cellular adhesion or proliferation, and biocompatibility of the material is not being altered. Results from physical, chemical, and mechanical effects confirm that varying dose rates alone do not initiate material changes, which negates the hypothesis that varying dose rates of radiation contribute to the complications in PICC and CVCs.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationShelley L. Cooke and Abby R. Whittington, “Investigation into Polyurethane at Varying Dose Rates of Ionizing Radiation for Clinical Application,” Journal of Chemistry, vol. 2018, Article ID 7312147, 8 pages, 2018. doi:10.1155/2018/7312147en
dc.identifier.doihttps://doi.org/10.1155/2018/7312147en
dc.identifier.urihttp://hdl.handle.net/10919/85265en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2018 Shelley L. Cooke and Abby R. Whittington. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleInvestigation into Polyurethane at Varying Dose Rates of Ionizing Radiation for Clinical Applicationen
dc.title.serialJournal of Chemistryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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