Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics

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dc.contributor.authorChen, Lien
dc.contributor.authorChoyke, Peter L.en
dc.contributor.authorWang, Niyaen
dc.contributor.authorClarke, Roberten
dc.contributor.authorBhujwalla, Zaver M.en
dc.contributor.authorHillman, Elizabeth M. C.en
dc.contributor.authorWang, Geen
dc.contributor.authorWang, Yueen
dc.contributor.departmentElectrical and Computer Engineeringen
dc.date.accessioned2018-10-03T18:10:23Zen
dc.date.available2018-10-03T18:10:23Zen
dc.date.issued2014-11-07en
dc.description.abstractWith the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the intermingled vascular compartments with distinct pharmacokinetics. However, intratumor vascular heterogeneity cannot be resolved directly by most in vivo dynamic imaging. We developed multi-tissue compartment modeling (MTCM), a completely unsupervised method of deconvoluting dynamic imaging series from heterogeneous tumors that can improve vascular characterization in many biological contexts. Applying MTCM to dynamic contrast-enhanced magnetic resonance imaging of breast cancers revealed characteristic intratumor vascular heterogeneity and therapeutic responses that were otherwise undetectable. MTCM is readily applicable to other dynamic imaging modalities for studying intratumor functional and phenotypic heterogeneity, together with a variety of foreseeable applications in the clinic.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0112143en
dc.identifier.eissn1932-6203en
dc.identifier.issue11en
dc.identifier.othere112143en
dc.identifier.pmid25379705en
dc.identifier.urihttp://hdl.handle.net/10919/85217en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleUnsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamicsen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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