The Structure and Function of Ionotropic Receptors in Drosophila

dc.contributor.authorNi, Linaen
dc.date.accessioned2021-05-26T14:11:01Zen
dc.date.available2021-05-26T14:11:01Zen
dc.date.issued2021-02-01en
dc.description.abstractIonotropic receptors (IRs) are a highly divergent subfamily of ionotropic glutamate receptors (iGluR) and are conserved across Protostomia, a major branch of the animal kingdom that encompasses both Ecdysozoa and Lophothrochozoa. They are broadly expressed in peripheral sensory systems, concentrated in sensory dendrites, and function in chemosensation, thermosensation, and hygrosensation. As iGluRs, four IR subunits form a functional ion channel to detect environmental stimuli. Most IR receptors comprise individual stimulus-specific tuning receptors and one or two broadly expressed coreceptors. This review summarizes the discoveries of the structure of IR complexes and the expression and function of each IR, as well as discusses the future direction for IR studies.en
dc.description.notesThis work was funded by NIH R01GM140130 and NIH R21MH122987 to LN.en
dc.description.sponsorshipNIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01GM140130, R21MH122987]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fnmol.2020.638839en
dc.identifier.issn1662-5099en
dc.identifier.other638839en
dc.identifier.pmid33597847en
dc.identifier.urihttp://hdl.handle.net/10919/103519en
dc.identifier.volume13en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectDrosophilaen
dc.subjectionotropic receptorsen
dc.subjectchemosensationen
dc.subjectgustationen
dc.subjectolfactionen
dc.subjectthermosensationen
dc.subjecthygrosensationen
dc.titleThe Structure and Function of Ionotropic Receptors in Drosophilaen
dc.title.serialFrontiers in Molecular Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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