Nontuberculous Mycobacteria in Household Plumbing as Possible Cause of Chronic Rhinosinusitis

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dc.contributor.authorTichenor, Wellington S.en
dc.contributor.authorThurlow, Jenniferen
dc.contributor.authorMcNulty, Stevenen
dc.contributor.authorBrown-Elliott, Barbara A.en
dc.contributor.authorWallace, Richard J. Jr.en
dc.contributor.authorFalkinham, Joseph O. IIIen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2019-08-20T12:42:10Zen
dc.date.available2019-08-20T12:42:10Zen
dc.date.issued2012-10en
dc.description.abstractSymptoms of chronic rhinosinusitis (CRS) often persist despite treatment. Because nontuberculous nnycobacteria (NTM) are resistant to commonly used antimicrobial drugs and are found in drinking water that patients may use for sinus irrigation, we investigated whether some CRS patients were infected with NTM in New York, New York, USA, during 2001-2011. Two approaches were chosen: 1) records of NTM-infected CRS patients were reviewed to identify common features of infection and Mycobacterium species; 2) samples from plumbing in households of 8 NTM-infected patients were cultured for NTM presence. In 3 households sampled, M. avium sharing rep-PCR and pulsed field gel electrophoresis fingerprints identified M. avium isolates clonally related to the patients' isolates. We conclude that patients with treatment-resistant CRS may be infected with NTM and should have cultures performed for NTM so appropriate therapy can be instituted. In addition, the results suggest that CRS patients can be infected by NTM in their household plumbing.en
dc.description.notesWork in the Mycobacteria/Nocardia Laboratory at the University of Texas Health Science Center was supported by the Amon Carter Foundation.en
dc.description.sponsorshipAmon Carter Foundationen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3201/eid1810.120164en
dc.identifier.eissn1080-6059en
dc.identifier.issn1080-6040en
dc.identifier.issue10en
dc.identifier.pmid23017381en
dc.identifier.urihttp://hdl.handle.net/10919/93189en
dc.identifier.volume18en
dc.language.isoenen
dc.rightsCreative Commons CC0 1.0 Universal Public Domain Dedicationen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subjecthuman-immunodeficiency-virusen
dc.subjectavium complexen
dc.subjectintracellulare complexen
dc.subjectinfectionen
dc.subjectdiseaseen
dc.subjectsinusitisen
dc.subjectgordonaeen
dc.subjectidentificationen
dc.subjectmanagementen
dc.subjectpathogensen
dc.titleNontuberculous Mycobacteria in Household Plumbing as Possible Cause of Chronic Rhinosinusitisen
dc.title.serialEmerging Infectious Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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