Cancer karyotypes: survival of the fittest

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dc.contributor.authorNicholson, Joshua M.en
dc.contributor.authorCimini, Danielaen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2019-11-05T13:49:50Zen
dc.date.available2019-11-05T13:49:50Zen
dc.date.issued2013en
dc.description.abstractCancer cells are typically characterized by complex karyotypes including both structural and numerical changes, with aneuploidy being a ubiquitous feature. It is becoming increasingly evident that aneuploidy per se can cause chromosome mis-segregation, which explains the higher rates of chromosome gain/loss observed in aneuploid cancer cells compared to normal diploid cells, a phenotype termed chromosomal instability (CIN). CIN can be caused by various mechanisms and results in extensive karyotypic heterogeneity within a cancer cell population. However, despite such karyotypic heterogeneity, cancer cells also display predominant karyotypic patterns. In this review we discuss the mechanisms of CIN, with particular emphasis on the role of aneuploidy on CIN. Further, we discuss the potential functional role of karyotypic patterns in cancer.en
dc.description.notesWe would like to thank all the members of the Cimini Lab for useful discussion and helpful comments. We also thank Giulia Rancati (Institute of Medical Biology, A-STAR, Singapore) for providing useful information and reference to scientific literature, and Neil Ganem (Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA) for providing clarifications on published data. Work in the Cimini Lab is supported by NSF grant MCB-0842551 and HFSP grant RGY0069/2010.en
dc.description.sponsorshipNSFNational Science Foundation (NSF) [MCB-0842551]; HFSPHuman Frontier Science Program [RGY0069/2010]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fonc.2013.00148en
dc.identifier.issn2234-943Xen
dc.identifier.other148en
dc.identifier.pmid23760367en
dc.identifier.urihttp://hdl.handle.net/10919/95250en
dc.identifier.volume3en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectaneuploidyen
dc.subjectkaryotypeen
dc.subjectCINen
dc.subjectcanceren
dc.subjectselectionen
dc.titleCancer karyotypes: survival of the fittesten
dc.title.serialFrontiers in Oncologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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