Reciprocal effects of the chirality and the surface functionalization on the drug delivery permissibility of carbon nanotubes

Simple item page
dc.contributorVirginia Tech. Engineering Science and Mechanics Departmenten
dc.contributor.authorSkandani, Amir A.en
dc.contributor.authorAl-Haik, Marwan S.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessed2015-04-17en
dc.date.accessioned2015-04-20T22:11:55Zen
dc.date.available2015-04-20T22:11:55Zen
dc.date.issued2013-10-24en
dc.description.abstractThe drug delivery admissibility of nanomaterials such as carbon nanotubes and their uncertain interactions with live tissues and organs have sparked ongoing research efforts. To boost the selective diffusivity of single walled carbon nanotubes (SWCNTs), surface functionalization was adopted in several experimental attempts. Numerous studies had identified polyethylene glycol (PEG) as a bio-compatible surfactant to carbon nanotubes. In this study, a large scale, atomistic molecular dynamic simulation was utilized to disclose the cellular exposure and uptake mechanisms of PEG-functionalized single walled carbon nanotubes (f-SWCNTs) into a lipid bilayer cell membrane. Results showed that with PEGs attached to a SWCNT, the penetration depth and speed can be controlled. Also, the simulations revealed that the adhesion energy between the nanotube and the lipid membrane is affected considerably, in the presence of PEGs, by the chirality of the SWCNTs.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSkandani, A. A., & Al-Haik, M. (2013). Reciprocal effects of the chirality and the surface functionalization on the drug delivery permissibility of carbon nanotubes. Soft Matter, 9(48), 11645-11649. doi: 10.1039/C3SM52126Een
dc.identifier.doihttps://doi.org/10.1039/C3SM52126Een
dc.identifier.issn1744-683Xen
dc.identifier.urihttp://hdl.handle.net/10919/51718en
dc.identifier.urlhttp://pubs.rsc.org/en/content/articlelanding/2013/sm/c3sm52126een
dc.language.isoen_USen
dc.publisherThe Royal Society of Chemistryen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectCarbon nanotubesen
dc.subjectDrug delivery mechanismsen
dc.subjectSingle-walled carbon nanotubesen
dc.titleReciprocal effects of the chirality and the surface functionalization on the drug delivery permissibility of carbon nanotubesen
dc.title.serialSoft Matteren
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2013_Skandani_Al-Haik.pdf
Size:
704.51 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Biomedical Engineering and Mechanics