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Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B

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dc.contributor.authorCardoso, R. A.en
dc.contributor.authorMelo Fihlo, A. A.en
dc.contributor.authorMelo, M. C. C.en
dc.contributor.authorLyerly, D. M.en
dc.contributor.authorWilkins, Tracy D.en
dc.contributor.authorLima, A. A. M.en
dc.contributor.authorRibeiro, R. A.en
dc.contributor.authorSouza, G. E. P.en
dc.contributor.departmentBiochemistryen
dc.date.accessed2014-06-11en
dc.date.accessioned2014-06-12T13:28:58Zen
dc.date.available2014-06-12T13:28:58Zen
dc.date.issued1996-06en
dc.description.abstractThis study investigated the ability of Clostridium difficile toxin B, isolated from the VPI 10463 strain, to induce fever and neutrophilia in rats. Intravenous injection of toxin B (0.005-0.5 mu g/kg) evoked a dose-dependent increase in body temperature. The febrile response to 0.5 mu g/kg of the toxin started in 2.5 h, peaked at 5 h, and subsided fully within 24 h. Toxin B also induced a dose-dependent neutrophilia. Pretreatment with indomethacin (2 mg/kg, i.p.) did not affect the neutrophilia induced by toxin B, but significantly reduced the febrile response measured 4 to 8 h after toxin B injection. Dexamethasone (0.5 mg/kg) also markedly diminished the febrile response induced by toxin B. These results show that Clostridium difficile toxin B induced a febrile response susceptible to inhibition by dexamethasone and indomethacin. Furthermore, they suggest that prostaglandins are not involved in the neutrophilia caused by this toxin.en
dc.description.sponsorshipFAPESPen
dc.description.sponsorshipCNPq.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationR. A. Cardoso, A. A. Melo Filho, M. C. C. Melo, et al., "Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B," Mediators of Inflammation, vol. 5, no. 3, pp. 183-187, 1996. doi:10.1155/S0962935196000245en
dc.identifier.doihttps://doi.org/10.1155/s0962935196000245en
dc.identifier.issn0962-9351en
dc.identifier.urihttp://hdl.handle.net/10919/48919en
dc.identifier.urlhttp://www.hindawi.com/journals/mi/1996/634354/cta/en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.rightsCreative Commons Attribution 3.0 Unporteden
dc.rights.holderCopyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectanti-inflammatory drugsen
dc.subjectclostridium difficile toxin ben
dc.subjectdexamethasoneen
dc.subjectfeveren
dc.subjectindomethacinen
dc.subjectneutrophiliaen
dc.subjecttumor-necrosis-factoren
dc.subjectpseudomembranous colitisen
dc.subjectcirculating numbersen
dc.subjectnucleotide-sequenceen
dc.subjectinduced antipyresisen
dc.subjecthuman-monocytesen
dc.subjectinvivoen
dc.subjectgeneen
dc.subjectraten
dc.subjectlipopolysaccharideen
dc.subjectcell biologyen
dc.subjectimmunologyen
dc.titleEffects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin Ben
dc.title.serialMediators of Inflammationen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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