F-spondin Is Essential for Maintaining Circadian Rhythms

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dc.contributor.authorCarrillo, Gabriela Lizanaen
dc.contributor.authorSu, Jianminen
dc.contributor.authorMonavarfeshani, Aboozaren
dc.contributor.authorFox, Michael A.en
dc.date.accessioned2018-11-19T18:32:00Zen
dc.date.available2018-11-19T18:32:00Zen
dc.date.issued2018-02-08en
dc.description.abstractThe suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian behaviors. SCN neurons have intrinsic, self-sustained rhythmicity that is governed by transcription-translation feedback loops. Intrinsic rhythms within the SCN do not match the day-night cycle and are therefore entrained by light-derived cues. Such cues are transmitted to the SCN by a class of intrinsically photosensitive retinal ganglion cells (ipRGCs). In the present study, we sought to identify how axons from ipRGCs target the SCN. While none of the potential targeting cues identified appeared necessary for retinohypothalamic innervation, we unexpectedly identified a novel role for the extracellular matrix protein F-spondin in circadian behavior. In the absence of F-spondin, mice lost their ability to maintain typical intrinsic rhythmicity. Moreover, F-spondin loss results in the displacement of vasoactive intestinal peptide (VIP)-expressing neurons, a class of neurons that are essential for maintaining rhythmicity among SCN neurons. Thus, this study highlights a novel role for F-spondin in maintaining circadian rhythms.en
dc.description.sponsorshipNational Institutes of Health—National Eye Instituteen
dc.description.sponsorshipNIMH: EY021222en
dc.description.sponsorshipNIMH: EY024712en
dc.description.sponsorshipVTCRIen
dc.identifier.doihttps://doi.org/10.3389/fncir.2018.00013en
dc.identifier.urihttp://hdl.handle.net/10919/85881en
dc.identifier.volume12en
dc.language.isoen_USen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsuprachiasmatic nucleusen
dc.subjectextracellular matrixen
dc.subjectcircadian rhythmen
dc.subjectphotoentrainmenten
dc.subjectintrinsically photosensitive retinal ganglion cellsen
dc.titleF-spondin Is Essential for Maintaining Circadian Rhythmsen
dc.title.serialFrontiers in Neural Circuitsen
dc.typeArticle - Refereeden
dc.type.dcmitypetexten

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