Editorial: Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation

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dc.contributor.authorLi, Liwuen
dc.contributor.authorMcCall, Charles E.en
dc.contributor.authorHu, Xiaoyuen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2020-05-15T15:02:43Zen
dc.date.available2020-05-15T15:02:43Zen
dc.date.issued2020-02-11en
dc.description.abstractEmerging studies reveal that “memory” responses of innate leukocytes generate adaptive reprogramming following challenges with signals of varying strength and durations. As a result, there are dynamic memory states such as priming, tolerance and exhaustion, as previously published by the Li research group in the Frontiers of Immunology (1). Diverse signals including microbial cues, cytokines, and metabolic products induce the varied reprogramming of inflammation and immunity, leading to distinct nature of the memory states of innate leukocytes. Innate memory dynamics profoundly impact, not only on our fundamental understanding of the immune system’s cohesive functions, but may translate to interventions for infectious and inflammatory diseases, ranging from acute sepsis to chronic atherosclerosis (2–4).en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fimmu.2020.00177en
dc.identifier.issn1664-3224en
dc.identifier.other177en
dc.identifier.pmid32117304en
dc.identifier.urihttp://hdl.handle.net/10919/98405en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectinnate immune memoryen
dc.subjectinflammation dynamicsen
dc.subjectresolving and non-resolving inflammationen
dc.subjectacute diseaseen
dc.subjectchronic diseaseen
dc.titleEditorial: Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammationen
dc.title.serialFrontiers in Immunologyen
dc.typeEditorialen
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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