The molecular mechanism linking muscle fat accumulation to insulin resistance

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dc.contributor.authorDohm, G. Lynisen
dc.contributor.authorHulver, Matthew W.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-10-12T15:12:51Zen
dc.date.available2017-10-12T15:12:51Zen
dc.date.issued2004en
dc.description.abstractSkeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the development of type 2 diabetes mellitus. Insulin resistance is associated with the accumulation of intramyocellular lipids. Intramyocellular triacylglycerols do not appear to be the cause of insulin resistance but are more likely to be a marker of other lipid intermediates such as fatty acyl-CoA, ceramides or diacylglycerols. Fatty acyl-CoA, ceramides and diacylglycerols are known to directly alter various aspects of the insulin signalling cascade. Insulin signalling is inhibited by the phosphorylation of serine and threonine residues at the levels of the insulin receptor and insulin receptor substrate 1. Protein kinase C is responsible for the phosphorylation of the serine and threonine residues. Fatty acyl-CoA and diacylglycerols are known to activate protein kinase C. The cause of the intramyocellular accumulation of fatty acyl-CoA and diacylglycerols is unclear at this time. Reduced fatty acid oxidation does not appear to be responsible, as fatty acyl-CoA accumulates in skeletal muscle with a normal fatty acid oxidative capacity. Other potential mechanisms include oversupply of lipids to muscle and/or up regulated fatty acid transport.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1079/PNS2004351en
dc.identifier.issue2en
dc.identifier.urihttp://hdl.handle.net/10919/79624en
dc.identifier.volume63en
dc.language.isoenen
dc.publisherThe Nutrition Societyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectinsulin resistanceen
dc.subjectintramyocellular lipidsen
dc.subjectfatty acyl-CoAen
dc.subjectdiacylglycerolsen
dc.titleThe molecular mechanism linking muscle fat accumulation to insulin resistanceen
dc.title.serialProceedings of the Nutrition Societyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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