Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells

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dc.contributor.authorHeyde, Keith C.en
dc.contributor.authorRuder, Warren C.en
dc.contributor.departmentBiological Systems Engineeringen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2019-01-25T15:47:46Zen
dc.date.available2019-01-25T15:47:46Zen
dc.date.issued2015-07-16en
dc.description.abstractThe microbiome's underlying dynamics play an important role in regulating the behavior and health of its host. In order to explore the details of these interactions, we created an in silico model of a living microbiome, engineered with synthetic biology, that interfaces with a biomimetic, robotic host. By analytically modeling and computationally simulating engineered gene networks in these commensal communities, we reproduced complex behaviors in the host. We observed that robot movements depended upon programmed biochemical network dynamics within the microbiome. These results illustrate the model's potential utility as a tool for exploring inter-kingdom ecological relationships. These systems could impact fields ranging from synthetic biology and ecology to biophysics and medicine.en
dc.description.notesThe authors gratefully acknowledge support from award FA9550-13-1-0108 from the Air Force Office of Scientific Research of the USA. This work was also supported in part by the National Science Foundation under Grant No. DGE-0966125. The authors also thank M.A. Stremler and M.K. Rice for insightful discussions and feedback.en
dc.description.sponsorshipAir Force Office of Scientific Research of the USA [FA9550-13-1-0108]; National Science Foundation [DGE-0966125]en
dc.format.extent12en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/srep11988en
dc.identifier.issn2045-2322en
dc.identifier.other11988en
dc.identifier.pmid26178309en
dc.identifier.urihttp://hdl.handle.net/10919/86894en
dc.identifier.volume5en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectstochastic gene-expressionen
dc.subjectregulatory networksen
dc.subjectescherichia-colien
dc.subjecttoggle switchen
dc.subjectbacteriaen
dc.subjectconstructionen
dc.subjectintegrationen
dc.subjectbehavioren
dc.subjectdesignen
dc.subjectnoiseen
dc.titleExploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cellsen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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