High-frequency electroporation for cancer therapy

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dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorDavalos, Rafael V.en
dc.contributor.inventorArena, Christopher B.en
dc.contributor.inventorSano, Michael B.en
dc.date.accessed2021-03-23en
dc.date.accessioned2021-03-25T18:15:40Zen
dc.date.available2021-03-25T18:15:40Zen
dc.date.filed2011-12-20en
dc.date.issued2019-10-22en
dc.description.abstractThe present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber13332133en
dc.identifier.patentnumber10448989en
dc.identifier.urihttp://hdl.handle.net/10919/102813en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/89/489/104/0.pdfen
dc.languageenen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA61B18/14en
dc.subject.cpcA61N1/327en
dc.subject.cpcA61B2018/0016en
dc.subject.cpcA61B2018/00577en
dc.subject.cpcA61B2018/00613en
dc.subject.cpcA61B2018/00761en
dc.subject.cpcA61B2018/00767en
dc.titleHigh-frequency electroporation for cancer therapyen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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