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Is sham cTBS real cTBS? The effect on EEG dynamics

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dc.contributor.authorOpitz, Alexanderen
dc.contributor.authorLegon, Wynnen
dc.contributor.authorMueller, Jerel K.en
dc.contributor.authorBarbour, Aaron J.en
dc.contributor.authorPaulus, Walteren
dc.contributor.authorTyler, William J.en
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2019-05-28T14:50:20Zen
dc.date.available2019-05-28T14:50:20Zen
dc.date.issued2015-01-08en
dc.description.abstractIncreasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5% that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fnhum.2014.01043en
dc.identifier.issn16625161en
dc.identifier.pmid25620925en
dc.identifier.urihttp://hdl.handle.net/10919/89618en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectDLPFCen
dc.subjectEEGen
dc.subjectTMSen
dc.subjectelectric fielden
dc.subjectevoked potentialsen
dc.subjectsham TMSen
dc.subjectsomatosensoryen
dc.titleIs sham cTBS real cTBS? The effect on EEG dynamicsen
dc.title.serialFrontiers in Human Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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