Alteration of Lysosome Fusion and Low-grade Inflammation Mediated by Super-low-dose Endotoxin
| dc.contributor.author | Baker, Bianca | en |
| dc.contributor.author | Geng, Shuo | en |
| dc.contributor.author | Chen, Keqiang | en |
| dc.contributor.author | Diao, Na | en |
| dc.contributor.author | Yuan, Ruoxi | en |
| dc.contributor.author | Xu, Xiguang | en |
| dc.contributor.author | Dougherty, Sean | en |
| dc.contributor.author | Stephenson, Caroline | en |
| dc.contributor.author | Xiong, Huabao | en |
| dc.contributor.author | Chu, Hong Wei | en |
| dc.contributor.author | Li, Liwu | en |
| dc.date.accessioned | 2021-04-26T13:58:15Z | en |
| dc.date.available | 2021-04-26T13:58:15Z | en |
| dc.date.issued | 2015-01-13 | en |
| dc.description.abstract | Background: Super-low-dose endotoxemia contributes to cell stress and low-grade inflammation. Results: Super-low-dose LPS removed Tollip from late endosomes/lysosomes and blocked lysosome fusion with endosomes or autophagosomes. Tollip knock-out mice had impaired wound healing. Conclusion: Super-low-dose LPS leads to cell stress through clearing Tollip and blocking lysosome fusion. Significance: Our data reveal molecular dynamics of innate immunity regulation. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | https://doi.org/10.1074/jbc.M114.611442 | en |
| dc.identifier.issue | 10 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/103122 | en |
| dc.identifier.volume | 290 | en |
| dc.language.iso | en | en |
| dc.publisher | American Society for Biochemistry and Molecular Biology, Inc | en |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.title | Alteration of Lysosome Fusion and Low-grade Inflammation Mediated by Super-low-dose Endotoxin | en |
| dc.title.serial | Journal of Biological Chemistry | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |