Identification and analysis of the N-6-methyladenosine in the Saccharomyces cerevisiae transcriptome

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dc.contributor.authorChen, Weien
dc.contributor.authorTran, Hong T.en
dc.contributor.authorLiang, Zhiyongen
dc.contributor.authorLin, Haoen
dc.contributor.authorZhang, Liqingen
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2019-01-25T15:47:45Zen
dc.date.available2019-01-25T15:47:45Zen
dc.date.issued2015-09-07en
dc.description.abstractKnowledge of the distribution of N-6-methyladenosine (m(6)A) is invaluable for understanding RNA biological functions. However, limitation in experimental methods impedes the progress towards the identification of m(6)A site. As a complement of experimental methods, a support vector machine based-method is proposed to identify m(6)A sites in Saccharomyces cerevisiae genome. In this model, RNA sequences are encoded by their nucleotide chemical property and accumulated nucleotide frequency information. It is observed in the jackknife test that the accuracy achieved by the proposed model in identifying the m(6)A site was 78.15%. For the convenience of experimental scientists, a webserver for the proposed model is provided at http://lin.uestc.edu.cn/server/m6Apred.php.en
dc.description.notesThis work was supported by National Nature Scientific Foundation of China (Nos. 61100092 and 61202256), Nature Scientific Foundation of Hebei Province (No. C2013209105), Program for the Top Young Innovative Talents of Higher Learning Institutions of Hebei Province (No. BJ2014028).en
dc.description.sponsorshipNational Nature Scientific Foundation of China [61100092, 61202256]; Nature Scientific Foundation of Hebei Province [C2013209105]; Program for the Top Young Innovative Talents of Higher Learning Institutions of Hebei Province [BJ2014028]en
dc.format.extent8en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/srep13859en
dc.identifier.issn2045-2322en
dc.identifier.other13859en
dc.identifier.pmid26343792en
dc.identifier.urihttp://hdl.handle.net/10919/86891en
dc.identifier.volume5en
dc.language.isoen_USen
dc.publisherSpringer Natureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmessenger-rnaen
dc.subjectpredictionen
dc.subjectrevealsen
dc.subjectrecognitionen
dc.subjectm(6)a-seqen
dc.subjectresiduesen
dc.subjectsitesen
dc.titleIdentification and analysis of the N-6-methyladenosine in the Saccharomyces cerevisiae transcriptomeen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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