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Potential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding process

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dc.contributorVirginia Techen
dc.contributor.authorHurton, Lenkaen
dc.contributor.authorBerkson, James M.en
dc.contributor.departmentFish and Wildlife Conservationen
dc.date.accessed2014-05-12en
dc.date.accessioned2014-05-14T14:36:48Zen
dc.date.available2014-05-14T14:36:48Zen
dc.date.issued2006-04en
dc.description.abstractBiomedical companies catch and bleed horseshoe crabs for the production of Limulus amebocyte lysate (LAL), a product used for protecting public health (Berkson and Shuster, 1999). LAL is a clotting agent, derived solely from horseshoe crab blood cells, which is used to detect the presence of pathogenic gramnegative bacteria in injectable drugs and implantable medical and dental devices (Mikkelsen, 1988; Novitsky, 1991). In addition, LAL is used in many diagnostic tests for such illnesses as gram-negative bacterial meningitis and typhoid fever (Ding and Ho, 2001). Because the LAL test allows one to detect femtogram levels of endotoxin (Ding and Ho, 2001), it is the most effective test for detecting endotoxin contamination, and its increasing use in medical and pharmaceutical laboratories makes it a highly valued product.en
dc.description.sponsorshipNOAA Office of Sea Grant, US Dept of Commerce, Grant no. NA96RG0025en
dc.identifier.citationHurton, Lenka and Berkson, Jim (2006). "Potential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding process," Fishery Bulletin, 104(2), pp. 293-298. http://fishbull.noaa.gov/1042/hurton.pdfen
dc.identifier.issn0090-0656en
dc.identifier.urihttp://hdl.handle.net/10919/48012en
dc.identifier.urlhttp://fishbull.noaa.gov/1042/hurton.pdfen
dc.language.isoen_USen
dc.publisherNational Marine Fisheries Service Scientific Publication Officeen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectdelaware bayen
dc.subjectblooden
dc.subjectfisheriesen
dc.titlePotential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding processen
dc.title.serialFishery Bulletinen
dc.typeArticleen

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