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Multivalent Brucella vaccine for protection against mycobacterial infections and methods of using the same

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dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorNammalwar, Sriranganathanen
dc.contributor.inventorAl Qublan, Hamzehen
dc.contributor.inventorBoyle, Stephen M.en
dc.contributor.inventorSchurig, Gerhardt G.en
dc.contributor.inventorSmith, Garretten
dc.date.accessed2021-03-23en
dc.date.accessioned2021-03-25T18:15:41Zen
dc.date.available2021-03-25T18:15:41Zen
dc.date.filed2015-09-08en
dc.date.issued2019-09-10en
dc.description.abstractProvided herein is a multivalent Brucella vaccine expressing at least one heterologous M. tuberculosis antigen. The vaccines described herein serve as an environmentally safe bivalent vaccine for protection against Brucella and Mycobacterium infections simultaneously. In particular, a multivalent vaccine comprising a Brucella strain transformed with a vector that expresses at least one M. tuberculosis antigen, where the M. tuberculosis antigen(s) is codon optimized for the Brucella strain is provided. In some aspects, the Brucella strain is B. abortus strain RB51 leuB and the M. tuberculosis antigen is one or more of Ag85B, Rv2660c, and ESAT6.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber15509381en
dc.identifier.patentnumber10406219en
dc.identifier.urihttp://hdl.handle.net/10919/102818en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/19/062/104/0.pdfen
dc.language.isoenen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA61K39/04en
dc.subject.cpcA61K35/74en
dc.subject.cpcA61K45/06en
dc.subject.cpcA61P31/06en
dc.subject.cpcA61K2039/523en
dc.subject.cpcA61K2039/552en
dc.subject.cpcA61K2039/70en
dc.subject.cpcC07K14/35en
dc.subject.cpcC12N1/20en
dc.subject.cpcC12N15/74en
dc.titleMultivalent Brucella vaccine for protection against mycobacterial infections and methods of using the sameen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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