Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice

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dc.contributor.authorKrahe, Thomas E.en
dc.contributor.authorSeabrook, Tania A.en
dc.contributor.authorChen, Ching-Kangen
dc.contributor.authorFox, Michael A.en
dc.contributor.authorGuido, Williamen
dc.date.accessioned2018-11-19T18:32:15Zen
dc.date.available2018-11-19T18:32:15Zen
dc.date.issued2012en
dc.description.abstractThe cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered sensory activity. DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening (delayed DR, DDR) and not after chronic DR (CDR) from birth.While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown. Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence. Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR. These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive.en
dc.description.sponsorshipNational Eye InstituteNEI: EY12716NEI: C-KC EY13811en
dc.description.sponsorshipNEI: MAF EY02122en
dc.identifier.doihttps://doi.org/10.1155/2012/426437en
dc.identifier.urihttp://hdl.handle.net/10919/85905en
dc.identifier.volume2012en
dc.language.isoen_USen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en
dc.titleModulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Miceen
dc.title.serialNeural Plasticityen
dc.typeArticle - Refereeden
dc.type.dcmitypetexten

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