STAT1 Regulates the Homeostatic Component of Visual Cortical Plasticity via an AMPA Receptor-Mediated Mechanism

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dc.contributor.authorVan Wart, Audraen
dc.contributor.authorNagakura, Ikueen
dc.contributor.authorPetravicz, Jeremyen
dc.contributor.authorTropea, Danielaen
dc.contributor.authorSur, Mrigankaen
dc.date.accessioned2018-03-22T14:16:21Zen
dc.date.available2018-03-22T14:16:21Zen
dc.date.issued2014-07-30en
dc.description.abstractAccumulating evidence points to a role for Janus kinase/signal transducers and activators of transcription (STAT) immune signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here we show that one of its components, STAT1, negatively regulates the homeostatic component of ocular dominance plasticity in visual cortex. After brief monocular deprivation (MD), STAT1 knock-out (KO) mice show an accelerated increase of open-eye responses, to a level comparable with open-eye responses after a longer duration of MD in wild-type (WT) mice. Therefore, this component of plasticity is abnormally enhanced in KO mice. Conversely, increasing STAT1 signaling by IFNy treatment in WT mice reduces the homeostatic component of plasticity by impairing open-eye responses. Enhanced plasticity inKOmice is accompanied by sustained surface levels of GluA1AMPAreceptors and increased amplitude and frequency of AMPA receptor-mediated mEPSCs, which resemble changes in WT mice after a longer duration of MD. These results demonstrate a unique role for STAT1 during visual cortical plasticity in vivo through a mechanism that includes AMPA receptors.en
dc.description.notespp.10256-10263en
dc.identifier.doihttps://doi.org/10.1523/JNEUROSCI.0189-14.2014en
dc.identifier.issue31en
dc.identifier.pmid25080587en
dc.identifier.urihttp://hdl.handle.net/10919/82538en
dc.identifier.urlhttp://www.jneurosci.org/content/34/31/10256en
dc.identifier.volume34en
dc.language.isoen_USen
dc.publisherSociety for Neuroscienceen
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/en
dc.subjectAMPA receptorsen
dc.subjectHomeostaticen
dc.subjectIFNyen
dc.subjectOcular dominance plasticityen
dc.subjectSTAT1en
dc.subjectVisual cortexen
dc.titleSTAT1 Regulates the Homeostatic Component of Visual Cortical Plasticity via an AMPA Receptor-Mediated Mechanismen
dc.title.serialJournal of Neuroscienceen
dc.typeArticle - Refereeden

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