Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission

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dc.contributor.authorAl Assal, Karinaen
dc.contributor.authorPrifti, Edien
dc.contributor.authorBelda, Eugenien
dc.contributor.authorSala, Priscilaen
dc.contributor.authorClement, Karineen
dc.contributor.authorDao, Maria-Carlotaen
dc.contributor.authorDore, Joelen
dc.contributor.authorLevenez, Florenceen
dc.contributor.authorTaddei, Carla R.en
dc.contributor.authorFonseca, Danielle Cristinaen
dc.contributor.authorRocha, Ilanna Marquesen
dc.contributor.authorBalmant, Bianca Depierien
dc.contributor.authorThomas, Andrew M.en
dc.contributor.authorSanto, Marco A.en
dc.contributor.authorDias-Neto, Emmanuelen
dc.contributor.authorSetubal, Joao Carlosen
dc.contributor.authorZucker, Jean-Danielen
dc.contributor.authorBelarmino, Gilianeen
dc.contributor.authorTorrinhas, Raquel Susanaen
dc.contributor.authorWaitzberg, Dan L.en
dc.date.accessioned2020-05-19T14:56:32Zen
dc.date.available2020-05-19T14:56:32Zen
dc.date.issued2020-02en
dc.description.abstractGut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. Objective: To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the correlation with food intake and postoperative type 2 diabetes remission (T2Dr). Design: Gut microbiota profile from obese diabetic women was evaluated before (n = 25) and 3 (n = 20) and 12 months (n = 14) after RYGB, using MiSeq Illumina-based V4 bacterial 16S rRNA gene profiling. Data on food intake (7-day record) and T2Dr (American Diabetes Association (ADA) criteria) were recorded. Results: Preoperatively, the abundance of five bacteria genera differed between patients with (57%) and without T2Dr (p < 0.050). Preoperative gut bacteria genus signature was able to predict the T2Dr status with 0.94 accuracy ROC curve (receiver operating characteristic curve). Postoperatively (vs. preoperative), the relative abundance of some gut bacteria genera changed, the gut microbial richness increased, and the Firmicutes to Bacteroidetes ratio (rFB) decreased (p < 0.05) regardless of T2Dr. Richness levels was correlated with dietary profile pre and postoperatively, mainly displaying positive and inverse correlations with fiber and lipid intakes, respectively (p < 0.05). Conclusions: Gut microbiota profile was influenced by RYGB and correlated with diet and T2Dr preoperatively, suggesting the possibility to assess its composition to predict postoperative T2Dr.en
dc.description.notesThis research was funded by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), project no.2011/09612-3. A.M.T. was supported by a FAPESP scholarship (15/01507-7). M.-C.D. and K.C. received funding from EU-Metacardis.en
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/09612-3]; FAPESP scholarshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/01507-7]; EU-Metacardisen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3390/nu12020278en
dc.identifier.eissn2072-6643en
dc.identifier.issue2en
dc.identifier.other278en
dc.identifier.pmid31973130en
dc.identifier.urihttp://hdl.handle.net/10919/98476en
dc.identifier.volume12en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbariatric surgeryen
dc.subjecttype 2 diabetes mellitusen
dc.subjectgut microbiotaen
dc.titleGut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remissionen
dc.title.serialNutrientsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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