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Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae

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dc.contributor.authorZhang, Jiantaoen
dc.contributor.authorWu, Chaochenen
dc.contributor.authorSheng, Jiayuanen
dc.contributor.authorFeng, Xueyangen
dc.contributor.departmentVirginia Tech. Department of Biological Systems Engineeringen
dc.contributor.departmentUniversity of Arizona. Department of Pharmacology & Toxicologyen
dc.contributor.departmentBiological Systems Engineeringen
dc.date.accessioned2017-05-01T06:42:18Zen
dc.date.available2017-05-01T06:42:18Zen
dc.date.issued2016-03-18en
dc.description.abstractWe report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synthesis of MH4 or BH4 cofactors. The innate DFR1 gene in the folate synthesis pathway was found to play pivotal roles in 5-hydroxytryptophan synthesis.en
dc.format.extent1432-1435en
dc.format.mimetypeapplication/pdfen
dc.identifierc5mb00888c.pdfen
dc.identifierc5mb00888c1.pdfen
dc.identifier.doihttps://doi.org/10.1039/c5mb00888cen
dc.identifier.eissn1742-2051en
dc.identifier.issn1742-206Xen
dc.identifier.issue5en
dc.identifier.urihttp://hdl.handle.net/10919/77563en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofRoyal Society of Chemistry Gold Open Access - 2016en
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.holderZhang, Jiantaoen
dc.rights.holderWu, Chaochenen
dc.rights.holderSheng, Jiayuanen
dc.rights.holderFeng, Xueyangen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.titleMolecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiaeen
dc.title.serialMolecular BioSystemsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeDataseten

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