Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors

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dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorWilkins, Tracy D.en
dc.contributor.inventorKrivan, Howard C.en
dc.date.accessed2016-08-19en
dc.date.accessioned2016-08-24T17:53:52Zen
dc.date.available2016-08-24T17:53:52Zen
dc.date.filed1986-02-11en
dc.date.issued1989-09-05en
dc.description.abstractA method is provided for detecting the presence of C. difficile toxin A. Stool or other appropriate specimen is contacted with a reagent containing an available non-reducing galactose-alpha-1-3-galactosyl structure, which is a specific receptor for toxin A. The reagent may be intact cells, cell membranes, membrane fractions containing the toxin A receptor structure, glycoconjugates, as well as the purified toxin A receptor per se. Binding of toxin A is determined by conventional assay techniques. The method may also be used to isolate and purify toxin A. Conversely, immobilized toxin A is used to detect, isolate, or purify biological materials of interest containing the receptor structure.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber6828404en
dc.identifier.patentnumber4863852en
dc.identifier.urihttp://hdl.handle.net/10919/72341en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/52/638/048/0.pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcG01N33/56911en
dc.subject.cpcY10S435/803en
dc.subject.cpcY10S435/842en
dc.subject.cpcY10S436/829en
dc.subject.cpcY10S530/825en
dc.subject.uspc435/7.25en
dc.subject.uspcother435/7.32en
dc.subject.uspcother435/7.92en
dc.subject.uspcother435/34en
dc.subject.uspcother435/39en
dc.subject.uspcother435/803en
dc.subject.uspcother435/842en
dc.subject.uspcother436/520en
dc.subject.uspcother436/534en
dc.subject.uspcother436/829en
dc.subject.uspcother530/413en
dc.subject.uspcother530/825en
dc.titleMethod of detecting, isolating and purifying clostridium difficile toxin A and its receptorsen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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