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Tumor Ablation with Irreversible Electroporation

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dc.contributor.authorAl-Sakere, Bassimen
dc.contributor.authorAndre, Francken
dc.contributor.authorBernat, Claireen
dc.contributor.authorConnault, Elisabethen
dc.contributor.authorOpolon, Pauleen
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.authorRubinsky, Borisen
dc.contributor.authorMir, Lluis M.en
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2018-11-15T14:43:31Zen
dc.date.available2018-11-15T14:43:31Zen
dc.date.issued2007-11-07en
dc.description.abstractWe report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the cell membrane. Mathematical models of the electrical and thermal fields that develop during the application of the pulses were used to design an efficient treatment protocol with minimal heating of the tissue. Tumor regression was confirmed by histological studies which also revealed that it occurred as a direct result of irreversible cell membrane permeabilization. Parametric studies show that the successful outcome of the procedure is related to the applied electric field strength, the total pulse duration as well as the temporal mode of delivery of the pulses. Our best results were obtained using plate electrodes to deliver across the tumor 80 pulses of 100 µs at 0.3 Hz with an electrical field magnitude of 2500 V/cm. These conditions induced complete regression in 12 out of 13 treated tumors, (92%), in the absence of tissue heating. Irreversible electroporation is thus a new effective modality for non-thermal tumor ablation.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0001135en
dc.identifier.eissn1932-6203en
dc.identifier.issue11en
dc.identifier.othere1135en
dc.identifier.pmid17989772en
dc.identifier.urihttp://hdl.handle.net/10919/85855en
dc.identifier.volume2en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleTumor Ablation with Irreversible Electroporationen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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