Cerium Oxide Nanoparticles Improve Outcome after In Vitro and In Vivo Mild Traumatic Brain Injury

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dc.contributor.authorBailey, Zachary S.en
dc.contributor.authorNilson, Ericen
dc.contributor.authorBates, John A.en
dc.contributor.authorOyalowo, Adewoleen
dc.contributor.authorHockey, Kevin S.en
dc.contributor.authorSajja, Venkata Siva Sai Sujithen
dc.contributor.authorThorpe, Chevon N.en
dc.contributor.authorRogers, Heidien
dc.contributor.authorDunn, Bryceen
dc.contributor.authorFrey, Aaron S.en
dc.contributor.authorBillings, Marc J.en
dc.contributor.authorSholar, Christopher A.en
dc.contributor.authorHermundstad, Amyen
dc.contributor.authorKumar, Challaen
dc.contributor.authorVandeVord, Pamela J.en
dc.contributor.authorRzigalinski, Beverly A.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2020-12-22T20:11:31Zen
dc.date.available2020-12-22T20:11:31Zen
dc.date.issued2020-06-15en
dc.description.abstractMild traumatic brain injury results in aberrant free radical generation, which is associated with oxidative stress, secondary injury signaling cascades, mitochondrial dysfunction, and poor functional outcome. Pharmacological targeting of free radicals with antioxidants has been examined as an approach to treatment, but has met with limited success in clinical trials. Conventional antioxidants that are currently available scavenge a single free radical before they are destroyed in the process. Here, we report for the first time that a novel regenerative cerium oxide nanoparticle antioxidant reduces neuronal death and calcium dysregulation after in vitro trauma. Further, using an in vivo model of mild lateral fluid percussion brain injury in the rat, we report that cerium oxide nanoparticles also preserve endogenous antioxidant systems, decrease macromolecular free radical damage, and improve cognitive function. Taken together, our results demonstrate that cerium oxide nanoparticles are a novel nanopharmaceutical with potential for mitigating neuropathological effects of mild traumatic brain injury and modifying the course of recovery.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1089/neu.2016.4644en
dc.identifier.eissn1557-9042en
dc.identifier.issn0897-7151en
dc.identifier.issue12en
dc.identifier.pmid27733104en
dc.identifier.urihttp://hdl.handle.net/10919/101579en
dc.identifier.volume37en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectcerium oxideen
dc.subjectnanoparticlesen
dc.subjectoxidative stressen
dc.subjecttraumatic brain injuryen
dc.titleCerium Oxide Nanoparticles Improve Outcome after In Vitro and In Vivo Mild Traumatic Brain Injuryen
dc.title.serialJournal of Neurotraumaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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